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初級

完成時間大約為17 小時

英語(English)

字幕:英語(English)

第 1 門課程(共 1 門)

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立即開始,按照自己的計劃學習。

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根據您的日程表重置截止日期。

初級

完成時間大約為17 小時

英語(English)

字幕:英語(English)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 3 小時

Week 1: Introduction to Evolutionary Tree Construction

<p>Welcome to our class!</p><p>In this class, we will consider the following two central biological&nbsp;questions (the computational approaches needed to solve them are shown in parentheses):</p><ol><li>Weeks 1-3: Which Animal Gave Us SARS? (<i>Evolutionary tree construction</i>)</li><li>Weeks 4-5: Was <em>T. rex</em> Just a Big Chicken?&nbsp;(<em>Combinatorial Algorithms</em>)</li></ol><p>In Week 6, you will complete a Bioinformatics Application Challenge to apply evolutionary tree construction algorithms in order to determine the origin of the recent ebola outbreak in Africa.</p><p>As in previous courses, each of these two chapters is accompanied by a Bioinformatics Cartoon created by talented artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What do stick bugs and bats have to do with deadly viruses? And how can bioinformatics be used to stop these viruses in their tracks? Start learning today and find out!</p><p><img src="http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" width="528"></p>

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5 個視頻 (總計 34 分鐘), 2 個閱讀材料, 3 個測驗
5 個視頻
Toward an Algorithm for Distance-Based Phylogeny Construction 8分鐘
Additive Phylogeny 9分鐘
2 個閱讀材料
Course Details10分鐘
Week 1 FAQs (Optional)
1 個練習
Week 1 Quiz15分鐘
2
完成時間為 3 小時

Week 2: More Algorithms for Constructing Trees from Distance Matrices

<p>Welcome to Week 2 of class!</p> <p>Last week, we started to see how evolutionary trees can be constructed from distance matrices. &nbsp;This week, we will encounter additional algorithms for this purpose, including the neighbor-joining algorithm, which has become one of the top-ten most cited papers in all of science since its introduction three decades ago.</p>

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3 個視頻 (總計 17 分鐘), 1 個閱讀材料, 3 個測驗
1 個閱讀材料
Week 2 FAQs (Optional)
1 個練習
Week 2 Quiz15分鐘
3
完成時間為 4 小時

Week 3: Constructing Evolutionary Trees from Characters

<p>Welcome to week 3 of class!</p> <p>Over the last two weeks, we have seen several different algorithms for constructing evolutionary trees from distance matrices.</p> <p>This week, we will conclude the current chapter by considering what happens if we use properties called "characters" instead of distances. We will also see how to infer the ancestral states of organisms in an evolutionary tree, and consider whether it is possible to define an efficient algorithm for this task.</p>

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4 個視頻 (總計 20 分鐘), 1 個閱讀材料, 3 個測驗
4 個視頻
Evolutionary Tree Reconstruction in the Modern Era 5分鐘
1 個閱讀材料
Week 3 FAQs (Optional)
1 個練習
Week 3 Quiz15分鐘
4
完成時間為 1 小時

Week 4

<p>Welcome to week 4 of the class!</p> <p>Did birds evolve from dinosaurs? Over the next two weeks, we will see how we could analyze molecular evidence in support of this theory. You can find this week's Bioinformatics Cartoon from Randall Christopher at the bottom of this E-mail. Why does the <em>T. rex&nbsp;</em>look so much like a chicken? And why is the monkey typing frantically? Keep learning to find out!</p> <p><img src="http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" width="528"></p>

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4 個視頻 (總計 26 分鐘), 1 個閱讀材料, 2 個測驗
4 個視頻
Peptide Sequencing 7分鐘
1 個閱讀材料
Note on This Week's Assignments10分鐘
1 個練習
Week 4 Quiz15分鐘
4.5
12 個審閱Chevron Right

來自Molecular Evolution (Bioinformatics IV)的熱門評論

創建者 RGJul 20th 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam

講師

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Pavel Pevzner

Professor
Department of Computer Science and Engineering
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Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

關於 加州大学圣地亚哥分校

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

關於 生物信息学 專項課程

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
生物信息学

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