關於此 專項課程
100% 在線課程

100% 在線課程

立即開始,按照自己的計劃學習。
靈活的計劃

靈活的計劃

設置並保持靈活的截止日期。
初級

初級

完成時間(小時)

完成時間大約為11 個月

建議 3 小時/週
可選語言

英語(English)

字幕:英語(English), 中文(簡體)...

您將獲得的技能

Whole Genome SequencingViterbi AlgorithmSuffix TreePython ProgrammingAlgorithmsUnweighted Pair Group Method with Arithmetic Mean (UPGMA)Bioinformatics
100% 在線課程

100% 在線課程

立即開始,按照自己的計劃學習。
靈活的計劃

靈活的計劃

設置並保持靈活的截止日期。
初級

初級

完成時間(小時)

完成時間大約為11 個月

建議 3 小時/週
可選語言

英語(English)

字幕:英語(English), 中文(簡體)...

專項課程 的運作方式

加入課程

Coursera 專項課程是幫助您掌握一門技能的一系列課程。若要開始學習,請直接註冊專項課程,或預覽專項課程並選擇您要首先開始學習的課程。當您訂閱專項課程的部分課程時,您將自動訂閱整個專項課程。您可以只完成一門課程,您可以隨時暫停學習或結束訂閱。訪問您的學生面板,跟踪您的課程註冊情況和進度。

實踐項目

每個專項課程都包括實踐項目。您需要成功完成這個(些)項目才能完成專項課程並獲得證書。如果專項課程中包括單獨的實踐項目課程,則需要在開始之前完成其他所有課程。

獲得證書

在結束每門課程並完成實踐項目之後,您會獲得一個證書,您可以向您的潛在雇主展示該證書並在您的職業社交網絡中分享。

how it works

此專項課程包含 7 門課程

課程1

Finding Hidden Messages in DNA (Bioinformatics I)

4.7
370 個評分
81 個審閱
Named a top 50 MOOC of all time by Class Central! This course begins a series of classes illustrating the power of computing in modern biology. Please join us on the frontier of bioinformatics to look for hidden messages in DNA without ever needing to put on a lab coat. In the first half of the course, we investigate DNA replication, and ask the question, where in the genome does DNA replication begin? We will see that we can answer this question for many bacteria using only some straightforward algorithms to look for hidden messages in the genome. In the second half of the course, we examine a different biological question, when we ask which DNA patterns play the role of molecular clocks. The cells in your body manage to maintain a circadian rhythm, but how is this achieved on the level of DNA? Once again, we will see that by knowing which hidden messages to look for, we can start to understand the amazingly complex language of DNA. Perhaps surprisingly, we will apply randomized algorithms, which roll dice and flip coins in order to solve problems. Finally, you will get your hands dirty and apply existing software tools to find recurring biological motifs within genes that are responsible for helping Mycobacterium tuberculosis go "dormant" within a host for many years before causing an active infection....
課程2

Genome Sequencing (Bioinformatics II)

4.8
162 個評分
34 個審閱
You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics. In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together. In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab. Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance....
課程3

Comparing Genes, Proteins, and Genomes (Bioinformatics III)

4.7
74 個評分
16 個審閱
Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST....
課程4

Molecular Evolution (Bioinformatics IV)

4.5
40 個評分
11 個審閱
In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time. In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans. In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination. Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines....

講師

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Pavel Pevzner

Professor
Department of Computer Science and Engineering
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Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering
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Nikolay Vyahhi

Visiting Scholar
Department of Computer Science and Engineering

關於 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

常見問題

  • 可以!点击您感兴趣的课程卡开始注册即可。注册并完成课程后,您可以获得可共享的证书,或者您也可以旁听该课程免费查看课程资料。如果您订阅的课程是某专项课程的一部分,系统会自动为您订阅完整的专项课程。访问您的学生面板,跟踪您的进度。

  • 此课程完全在线学习,无需到教室现场上课。您可以通过网络或移动设备随时随地访问课程视频、阅读材料和作业。

  • 此专项课程不提供大学学分,但部分大学可能会选择接受专项课程证书作为学分。查看您的合作院校了解详情。

  • The print companion accompanying the Specialization is Bioinformatics Algorithms: An Active Learning Approach (Vols. 1 and 2).

  • Time to completion can vary based on your schedule, but most learners are able to complete the Specialization in 4-6 months.

  • We require only a basic knowledge of high school-level biology and the ability to think technically.

  • We recommend taking the courses in the order presented, as each subsequent course will build on material from previous courses.

  • You will understand the ideas behind many different software tools that are used every day by biotech researchers, and you will know how to apply these tools to real datasets.

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