課程信息
4.8
158 個評分
34 個審閱
專項課程

第 2 門課程(共 7 門),位於

100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為15 小時

建議:3 hours/week...
可選語言

英語(English)

字幕:英語(English), 中文(簡體)...

您將獲得的技能

AlgorithmsPython ProgrammingWhole Genome SequencingDynamic Programming
專項課程

第 2 門課程(共 7 門),位於

100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為15 小時

建議:3 hours/week...
可選語言

英語(English)

字幕:英語(English), 中文(簡體)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 4 小時

Week 1: Introduction to Genome Sequencing

<p>Welcome to class!</p><p>This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:</p><ol><li>Weeks 1-2: How Do We Assemble Genomes? (<i>Graph Algorithms</i>)</li><li>How Do We Sequence Antibiotics? (<i>Brute Force Algorithms</i>)</li></ol><p>Each of the two chapters of content in the class is accompanied by a Bioinformatics Cartoon created by talented San Diego artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What does a time machine trip to 1735, a stack of newspapers, a jigsaw puzzle, and a giant ant invading a riverside city have to do with putting together a genome? Start learning today to find out!</p><p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter4_final_lr.jpg" width="528"></p>...
Reading
8 個視頻(共 36 分鐘), 2 個閱讀材料, 3 個測驗
Video8 個視頻
FIELD TRIP!4分鐘
What Is Genome Sequencing?6分鐘
Exploding Newspapers4分鐘
The String Reconstruction Problem3分鐘
String Reconstruction as a Hamiltonian Path Problem3分鐘
String Reconstruction as an Eulerian Path Problem5分鐘
Similar Problems with Different Fates 3分鐘
Reading2 個閱讀材料
Course Details10分鐘
Week 1 FAQs (Optional)分鐘
Quiz1 個練習
Week 1 Quiz15分鐘
2
完成時間(小時)
完成時間為 3 小時

Week 2: Applying Euler's Theorem to Assemble Genomes

<p>Welcome to Week 2 of class!</p> <p>This week in class, we will see how a 300 year-old mathematical theorem will help us assemble a genome from millions of tiny pieces of DNA.</p>...
Reading
5 個視頻(共 28 分鐘), 1 個閱讀材料, 3 個測驗
Video5 個視頻
Euler's Theorem 6分鐘
Assembling Read-Pairs 8分鐘
De Bruijn Graphs Face Harsh Realities of Assembly 4分鐘
Returning to Konigsberg 1分鐘
Reading1 個閱讀材料
Week 2 FAQs (Optional)分鐘
Quiz1 個練習
Week 2 Quiz15分鐘
3
完成時間(小時)
完成時間為 4 小時

Week 3: Sequencing Antibiotics

<p>Welcome to Week 3 of class!</p> <p>This week, we begin a new chapter, titled "How Do We Sequence Antibiotics?" &nbsp;In this chapter, we will learn&nbsp;how to determine the amino acid sequences making up antibiotics using brute force algorithms.</p> <p>Below is this week's Bioinformatics Cartoon.</p> <p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter2_final.jpg" width="528"></p>...
Reading
5 個視頻(共 27 分鐘), 1 個閱讀材料, 3 個測驗
Video5 個視頻
How Do Bacteria Make Antibiotics? 8分鐘
Sequencing Antibiotics by Shattering Them into Pieces 4分鐘
A Brute Force Algorithm for Cyclopeptide Sequencing 3分鐘
Cyclopeptide Sequencing with Branch and Bound 6分鐘
Reading1 個閱讀材料
Week 3 FAQs (Optional)分鐘
Quiz1 個練習
Week 3 Quiz15分鐘
4
完成時間(小時)
完成時間為 3 小時

Week 4: From Ideal to Real Spectra for Antibiotics Sequencing

<p>Welcome to Week 4 of class!</p> <p>Last week, we discussed how to sequence an antibiotic peptide from an ideal spectrum. This week, we will see how to develop more sophisticated algorithms for antibiotic peptide sequencing that are able to handle spectra with many false and missing masses.</p>...
Reading
4 個視頻(共 18 分鐘), 1 個閱讀材料, 3 個測驗
Video4 個視頻
From 20 to More than 100 Amino Acids 2分鐘
The Spectral Convolution Saves the Day 6分鐘
The Truth About Spectra 2分鐘
Reading1 個閱讀材料
Week 4 FAQs (Optional)分鐘
Quiz1 個練習
Week 4 Quiz15分鐘
4.8
職業方向

50%

完成這些課程後已開始新的職業生涯
工作福利

83%

通過此課程獲得實實在在的工作福利

熱門審閱

創建者 SVJan 10th 2017

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

創建者 MPDec 8th 2017

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

講師

Avatar

Pavel Pevzner

Professor
Department of Computer Science and Engineering
Avatar

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

關於 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

關於 Bioinformatics 專項課程

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

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