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Molecular Evolution (Bioinformatics IV), University of California San Diego

40 個評分
11 個審閱


In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time. In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans. In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination. Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines....


創建者 RG

Jul 20, 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam


10 個審閱

創建者 clearclouds

Sep 16, 2018


創建者 Dr Samuel Channon

Aug 17, 2018

Fascinating material, and excellently presented!

創建者 Christiane Andries

Nov 06, 2017

Good course material and challenging code problems!

Onde remark : the peer review was almost impossible to correct because the diagrams (trees) where of such lpoor quality that the numvers where almost completely unreadable!

創建者 Hercules Pereira Neves

Aug 15, 2017

Although certain aspects of it were positive and in line with the quality of previous modules, this course had its problems. The biggest was the lack of alignment between weeks 4 and 5 (which would be better placed in Module 2) and the rest of it. It got worse due to the lack of Stepik support and material in the textbooks that would in theory accompany the course. This misalignment is also evident when we look at the quizzes and the final challenge, which hardly tackled the material of those two dreadful weeks.

創建者 Robert Goldberg-Alberts

Jul 20, 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam

創建者 Arun Prasanna

May 09, 2017

It was an excellent & informative course !

創建者 Ari Belenkiy

Dec 05, 2016

At some point several instructors lost necessary passion to keep us focused. Otherwise it was a very informed and enjoyable presentation. Historical references are extremely important.

創建者 Weidong Xu

Oct 30, 2016


創建者 Yulan Wang

Oct 02, 2016

very useful!

創建者 Bryan Griffiths

Aug 15, 2016

I would have enjoyed it more if I had had enough knowledge to do the Honors quiz!

I downloaded all the videos so I could play them over without chewing up my data, but the quality is so poor you can't always make out the writing - i's and j's all look similar. It would be better if the presentation material was bigger and the facilitator images smaller - you need only see a face, not the whole upper body in the foreground.

Nevertheless, I have been enlightened !