課程信息
4.7
367 個評分
81 個審閱
專項課程

第 1 門課程(共 7 門),位於

100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為13 小時

建議:4-10 hours/week...
可選語言

英語(English)

字幕:英語(English)...

您將獲得的技能

BioinformaticsBioinformatics AlgorithmsAlgorithmsPython Programming
專項課程

第 1 門課程(共 7 門),位於

100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為13 小時

建議:4-10 hours/week...
可選語言

英語(English)

字幕:英語(English)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 3 小時

Week 1: Welcome!

<p>Welcome to class!</p><p>This course will focus on two questions at the forefront of modern computational biology, along with the algorithmic approaches we will use to solve them in parentheses:</p><ol><li>Weeks 1-2: Where in the Genome Does DNA Replication Begin? (<em>Algorithmic Warmup</em>)</li><li>Weeks 3-4: Which DNA Patterns Play the Role of Molecular Clocks? (<em>Randomized Algorithms</em>)</li></ol><p>Week 5 will consist of a Bioinformatics Application Challenge in which you will get to apply software for finding DNA motifs to a real biological dataset.</p><p>Each of the two chapters in the course is accompanied by a Bioinformatics Cartoon created by Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What does a cryptic message leading to buried treasure have to do with biology? We hope you will join us to find out!</p><p><img src="http://bioinformaticsalgorithms.com/images/cover/replication_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/chapter1_cropped.jpg" width="500"></p><p><a href="http://compeau.cbd.cmu.edu" target="_blank"><img src="http://bioinformaticsalgorithms.com/images/Compeau_caricature.jpg" width ="150"></a> <a href="http://cseweb.ucsd.edu/~ppevzner/" target="_blank"><img src="http://bioinformaticsalgorithms.com/images/Pevzner_caricature.jpg" width ="150"></a></p><p>Phillip and Pavel</p>...
Reading
3 個視頻(共 21 分鐘), 3 個閱讀材料, 3 個測驗
Video3 個視頻
Where in the Genome Does DNA Replication Begin? (Part 1) (11:37)11分鐘
Where in the Genome Does DNA Replication Begin? (Part 2) (06:24)6分鐘
Reading3 個閱讀材料
Course Details10分鐘
Week 1 FAQs (Optional)分鐘
What is Pseudocode? (Optional)1分鐘
Quiz1 個練習
Week 1 Quiz15分鐘
2
完成時間(小時)
完成時間為 3 小時

Week 2: Finding Replication Origins

<p>Welcome to Week 2 of class!</p> <p>This week, we will examine the biological details of how DNA replication is carried out in the cell. We will then see how to use these details to help us design an intelligent algorithmic approach looking for the replication origin in a bacterial genome.</p>...
Reading
2 個視頻(共 13 分鐘), 1 個閱讀材料, 3 個測驗
Video2 個視頻
Where in the Genome Does DNA Replication Begin? (Part 4) (04:10)4分鐘
Reading1 個閱讀材料
Week 2 FAQs (Optional)分鐘
Quiz1 個練習
Week 2 Quiz15分鐘
3
完成時間(小時)
完成時間為 4 小時

Week 3: Hunting for Regulatory Motifs

<p>Welcome to Week 3 of class!</p> <p>This week, we begin a new chapter, titled "Which DNA Patterns Play the Role of Molecular Clocks?" At the bottom of this message is this week's Bioinformatics Cartoon. &nbsp;What does a late night casino trip with two 18th Century French mathematicians have in common with finding molecular clocks? &nbsp;Start learning to find out...</p> <p><img src="https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter3_final.jpg" title="Image: https://d396qusza40orc.cloudfront.net/bioinformatics%2Fimages%2Fchapter3_final.jpg" width="528"></p>...
Reading
3 個視頻(共 23 分鐘), 1 個閱讀材料, 3 個測驗
Video3 個視頻
From Implanted Patterns to Regulatory Motifs (Part 2) (05:06)5分鐘
From Implanted Patterns to Regulatory Motifs (Part 3) (07:22)7分鐘
Reading1 個閱讀材料
Week 3 FAQs (Optional)分鐘
Quiz1 個練習
Week 3 Quiz15分鐘
4
完成時間(小時)
完成時間為 3 小時

Week 4: How Rolling Dice Helps Us Find Regulatory Motifs

<p>Welcome to Week 4 of class!</p> <p>Last week, we encountered a few introductory motif-finding algorithms. This week, we will see how to improve upon these motif-finding approaches by designing randomized algorithms that can "roll dice" to find motifs.</p>...
Reading
3 個視頻(共 26 分鐘), 1 個閱讀材料, 3 個測驗
Video3 個視頻
How Rolling Dice Helps Us Find Regulatory Motifs (Part 2) (05:37)5分鐘
How Rolling Dice Helps Us Find Regulatory Motifs (Part 3) (07:46)7分鐘
Reading1 個閱讀材料
Week 4 FAQs (Optional)分鐘
Quiz1 個練習
Week 4 Quiz15分鐘
4.7
職業方向

33%

完成這些課程後已開始新的職業生涯
工作福利

83%

通過此課程獲得實實在在的工作福利

熱門審閱

創建者 LLNov 13th 2017

Very tough but rewarding class. The programming part was easy, the algorithms kicked my butt. Love the challenge and can't wait to take the rest!!! Such an interesting field!

創建者 MPDec 4th 2017

Nice and recommended.\n\n(The final exam was a bit tedious though, with many points repeatedly given simply for "uploading the logo" and not much creative leeway)

講師

Avatar

Pavel Pevzner

Professor
Department of Computer Science and Engineering
Avatar

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

關於 University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

關於 Bioinformatics 專項課程

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

常見問題

  • 注册以便获得证书后,您将有权访问所有视频、测验和编程作业(如果适用)。只有在您的班次开课之后,才可以提交和审阅同学互评作业。如果您选择在不购买的情况下浏览课程,可能无法访问某些作业。

  • 您注册课程后,将有权访问专项课程中的所有课程,并且会在完成课程后获得证书。您的电子课程证书将添加到您的成就页中,您可以通过该页打印您的课程证书或将其添加到您的领英档案中。如果您只想阅读和查看课程内容,可以免费旁听课程。

還有其他問題嗎?請訪問 學生幫助中心