關於此課程：In this course, you will learn how to use the BaseSpace cloud platform developed by Illumina (our industry partner) to apply several standard bioinformatics software approaches to real biological data. In particular, in a series of Application Challenges will see how genome assembly can be used to track the source of a food poisoning outbreak, how RNA-Sequencing can help us analyze gene expression data on the tissue level, and compare the pros and cons of whole genome vs. whole exome sequencing for finding potentially harmful mutations in a human sample. Plus, hacker track students will have the option to build their own genome assembler and apply it to real data!
此課程適用人群：This course is aimed at technically-minded students who have completed the first six courses in the Bioinformatics Specialization.
製作方： University of California San Diego
教學方： Phillip Compeau, Visiting Researcher
Department of Computer Science & Engineering教學方： Pavel Pevzner, Professor
Department of Computer Science and Engineering
| 基本信息 | 課程 7（共 7 門，Bioinformatics Specialization ） |
| 級別 | 初級 |
| 承諾學習時間 | 3 weeks of study, 3-4 hours/week |
| 語言 | English |
| 如何通過 | 通過所有計分作業以完成課程。 |
| 用戶評分 |
授課大綱
第 1 週
Week 1: Identifying the Culprit in a Food Poisoning Outbreak
This week, we will apply genome sequencing algorithms to identify the bacterium causing a deadly food poisoning outbreak.
4 個閱讀材料
- Reading: Welcome to Class!
- Reading: Special Thanks
- Reading: Introduction
- Reading: Databases and Tools
已評分: Application Challenge 1
第 2 週
Week 2: Comparing Gene Expression in Tissue Samples with RNA-Seq
In this week's Application Challenge, we will learn how RNA-Sequencing can be applied to perform tissue-level gene expression analysis. In particular, which is more similar on a gene expression level: different tissues from the same organism, or analogous tissues from related species? This question was the subject of recent debate and a Twitter controversy -- read more to find out!
2 個閱讀材料
- Reading: Introduction
- Reading: Databases and Tools
已評分: Application Challenge 2
第 3 週
Week 3: Weighing the Pros and Cons of Whole Genome and Whole Exome Sequencing on a Human Sample
Comparing the differences between sequencing an entire human genome and sequencing only the exome, or the DNA that is eventually translated into protein. Can we obtain a complete picture of someone's genetic disease predispositions from only the exome, or is there information lurking in introns that can provide doctors with vital information? How do we weigh the trade-offs when considering genome and exome sequencing?
4 個閱讀材料
- Reading: Introduction
- Reading: Databases and Tools
- Reading: Walkthroughs
- Reading: Reading: Part 3 FAQs
已評分: Application Challenge 3
常見問題解答
運作方式
Coursework
Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.
Help from Your Peers
Connect with thousands of other learners and debate ideas, discuss course material, and get help mastering concepts.
Certificates
Earn official recognition for your work, and share your success with friends, colleagues, and employers.
製作方
University of California San Diego
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory.
價格
| 購買課程 | |
|---|---|
| 訪問課程材料 | 可用 |
| 訪問評分的材料 | 可用 |
| 收到最終成績 | 可用 |
| 獲得可共享的課程證書 | 可用 |
評分和審閱
Great course and specialization!!
TW
This specialization is well organized, and the stepik interactive textbook is a splendid tool for learning. I learned a lot about bioinformatics algorithms from this specialization, especially from the programming assignments.