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4.8
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While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability. Importantly, unlike genetic mutations, epigenetic modifications are reversible and therefore have the potential to be manipulated therapeutically. It has also become clear in recent years that epigenetic modifications are sensitive to the environment (for example diet), which has sparked a large amount of public debate and research. This course will give an introduction to the fundamentals of epigenetic control. We will examine epigenetic phenomena that are manifestations of epigenetic control in several organisms, with a focus on mammals. We will examine the interplay between epigenetic control and the environment and finally the role of aberrant epigenetic control in disease. All necessary information will be covered in the lectures, and recommended and required readings will be provided. There are no additional required texts for this course. For those interested, additional information can be obtained in the following textbook. Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13: 978-0879697242 | Edition: 1...
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建議:7 weeks of study, 6-8 hours/week

完成時間大約為29 小時
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CancerMolecular BiologyCancer EpigeneticsDna Methylation
Globe

100% 在線課程

立即開始,按照自己的計劃學習。
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建議:7 weeks of study, 6-8 hours/week

完成時間大約為29 小時
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1

章節
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完成時間為 2 小時

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability. ...
Reading
7 個視頻(共 65 分鐘), 5 個閱讀材料, 1 個測驗
Video7 個視頻
1.1 Introduction to the concepts of epigenetic control10分鐘
1.2 Mitotic heritability of epigenetic marks10分鐘
1.3 Chromatin and the nucleosome6分鐘
1.4 Chromatin compaction - heterochromatin versus euchromatin9分鐘
1.5 DNA methylation at CpG islands11分鐘
1.6 DNA methylation at intergenic regions and repetitive elements15分鐘
Reading5 個閱讀材料
Course syllabus10分鐘
Teaching team10分鐘
Start of course survey10分鐘
Assessment and grading policy10分鐘
Week 1 and 2 resources10分鐘
Quiz1 個練習
Week 1 quiz - contributes 8% towards your final grade20分鐘

2

章節
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完成時間為 2 小時

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course. ...
Reading
9 個視頻(共 90 分鐘), 1 個閱讀材料, 1 個測驗
Video9 個視頻
2.2 Histone acetylation and histone methylation12分鐘
2.3 Chromatin remodelling12分鐘
2.4 Histone variants8分鐘
2.5 Noncoding RNAs - microRNAs6分鐘
2.6 Noncoding RNAs - piRNAs9分鐘
2.7 Noncoding RNAs - long noncoding RNAs introduction10分鐘
2.8 Long noncoding RNAs Xist and HOTAIR7分鐘
2.9 3D organisation of the nucleus and summary of epigenetic marks17分鐘
Reading1 個閱讀材料
Week 1 and 2 resources10分鐘
Quiz1 個練習
Week 2 quiz - contributes 8% towards your final grade20分鐘

3

章節
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完成時間為 3 小時

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms. ...
Reading
12 個視頻(共 113 分鐘), 1 個閱讀材料, 1 個測驗
Video12 個視頻
3.2 Timing of random and imprinted X chromosome inactivation8分鐘
3.3 Stages of X inactivation - counting and control of Xist expression13分鐘
3.4 Control of Xist expression by pluripotency factors6分鐘
3.5 Stages of X inactivation - choice of which X to inactivate9分鐘
3.6 Stages of X inactivation - initiation and spreading of silencing11分鐘
3.7 Stages of X inactivation - establishment of silencing6分鐘
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18分鐘
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18分鐘
3.10 X chromosome inactivation summary10分鐘
3.11 Dosage compensation in flies and worms, compared with mammals8分鐘
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10分鐘
Reading1 個閱讀材料
Week 3 resources (including required readings)10分鐘
Quiz1 個練習
Week 3 quiz - contributes 12% towards your final grade30分鐘

4

章節
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完成時間為 2 小時

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth....
Reading
6 個視頻(共 68 分鐘), 1 個閱讀材料, 1 個測驗
Video6 個視頻
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11分鐘
4.3 Location of imprinted genes in the genome and bisulfite sequencing10分鐘
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17分鐘
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13分鐘
4.6 Summary of epigenetic reprogramming and imprinting6分鐘
Reading1 個閱讀材料
Week 4 resources (including required reading)10分鐘
Quiz1 個練習
Week 4 quiz - contributes 12% towards your final grade30分鐘
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創建者 DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

創建者 BMAug 14th 2017

One of the best organized and implemented courses I have taken so far. For someone who had barely any experience with epigenetics, I feel this gave me a proper introduction to the field.

講師

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

關於 The University of Melbourne

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

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