課程信息
27,217 次近期查看

100% 在線

立即開始,按照自己的計劃學習。

可靈活調整截止日期

根據您的日程表重置截止日期。

完成時間大約為30 小時

建議:7 weeks of study, 6-8 hours/week...

英語(English)

字幕:英語(English), 西班牙語(Spanish)

您將獲得的技能

CancerMolecular BiologyCancer EpigeneticsDna Methylation

100% 在線

立即開始,按照自己的計劃學習。

可靈活調整截止日期

根據您的日程表重置截止日期。

完成時間大約為30 小時

建議:7 weeks of study, 6-8 hours/week...

英語(English)

字幕:英語(English), 西班牙語(Spanish)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 2 小時

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.

...
7 個視頻 (總計 65 分鐘), 5 個閱讀材料, 1 個測驗
7 個視頻
1.1 Introduction to the concepts of epigenetic control10分鐘
1.2 Mitotic heritability of epigenetic marks10分鐘
1.3 Chromatin and the nucleosome6分鐘
1.4 Chromatin compaction - heterochromatin versus euchromatin9分鐘
1.5 DNA methylation at CpG islands11分鐘
1.6 DNA methylation at intergenic regions and repetitive elements15分鐘
5 個閱讀材料
Course syllabus10分鐘
Teaching team10分鐘
Start of course survey10分鐘
Assessment and grading policy10分鐘
Week 1 and 2 resources10分鐘
1 個練習
Week 1 quiz - contributes 8% towards your final grade20分鐘
2
完成時間為 2 小時

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.

...
9 個視頻 (總計 90 分鐘), 1 個閱讀材料, 1 個測驗
9 個視頻
2.2 Histone acetylation and histone methylation12分鐘
2.3 Chromatin remodelling12分鐘
2.4 Histone variants8分鐘
2.5 Noncoding RNAs - microRNAs6分鐘
2.6 Noncoding RNAs - piRNAs9分鐘
2.7 Noncoding RNAs - long noncoding RNAs introduction10分鐘
2.8 Long noncoding RNAs Xist and HOTAIR7分鐘
2.9 3D organisation of the nucleus and summary of epigenetic marks17分鐘
1 個閱讀材料
Week 1 and 2 resources10分鐘
1 個練習
Week 2 quiz - contributes 8% towards your final grade20分鐘
3
完成時間為 3 小時

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.

...
12 個視頻 (總計 113 分鐘), 1 個閱讀材料, 1 個測驗
12 個視頻
3.2 Timing of random and imprinted X chromosome inactivation8分鐘
3.3 Stages of X inactivation - counting and control of Xist expression13分鐘
3.4 Control of Xist expression by pluripotency factors6分鐘
3.5 Stages of X inactivation - choice of which X to inactivate9分鐘
3.6 Stages of X inactivation - initiation and spreading of silencing11分鐘
3.7 Stages of X inactivation - establishment of silencing6分鐘
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18分鐘
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18分鐘
3.10 X chromosome inactivation summary10分鐘
3.11 Dosage compensation in flies and worms, compared with mammals8分鐘
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10分鐘
1 個閱讀材料
Week 3 resources (including required readings)10分鐘
1 個練習
Week 3 quiz - contributes 12% towards your final grade30分鐘
4
完成時間為 2 小時

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.

...
6 個視頻 (總計 68 分鐘), 1 個閱讀材料, 1 個測驗
6 個視頻
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11分鐘
4.3 Location of imprinted genes in the genome and bisulfite sequencing10分鐘
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17分鐘
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13分鐘
4.6 Summary of epigenetic reprogramming and imprinting6分鐘
1 個閱讀材料
Week 4 resources (including required reading)10分鐘
1 個練習
Week 4 quiz - contributes 12% towards your final grade30分鐘
4.8
112 個審閱Chevron Right

29%

完成這些課程後已開始新的職業生涯

36%

通過此課程獲得實實在在的工作福利

11%

加薪或升職

來自基因表达的表观遗传调控的熱門評論

創建者 MMOct 2nd 2018

This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.

創建者 DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

講師

Avatar

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

關於 墨尔本大学

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

常見問題

  • 注册以便获得证书后,您将有权访问所有视频、测验和编程作业(如果适用)。只有在您的班次开课之后,才可以提交和审阅同学互评作业。如果您选择在不购买的情况下浏览课程,可能无法访问某些作业。

  • 您购买证书后,将有权访问所有课程材料,包括评分作业。完成课程后,您的电子课程证书将添加到您的成就页中,您可以通过该页打印您的课程证书或将其添加到您的领英档案中。如果您只想阅读和查看课程内容,可以免费旁听课程。

還有其他問題嗎?請訪問 學生幫助中心