課程信息
4.8
143 個評分
30 個審閱
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完成時間(小時)

完成時間大約為14 小時

建議:2-4 hours/week...
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英語(English)

字幕:英語(English)...
100% online

100% online

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
完成時間(小時)

完成時間大約為14 小時

建議:2-4 hours/week...
可選語言

英語(English)

字幕:英語(English)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 3 小時

UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE

The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules....
Reading
11 個視頻(共 120 分鐘), 1 個閱讀材料, 1 個測驗
Video11 個視頻
Introduction to Personalized Medicine11分鐘
Genetics Definitions, Part I14分鐘
Genetics Definitions, Part II & Types of Genetic Variants15分鐘
Data Analysis, Part I: What is a Good Study?12分鐘
Data Analysis, Part II: What is a Good Test?7分鐘
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13分鐘
Variability in Drug Therapy15分鐘
Drug Metabolism & Transport13分鐘
Genetic Variability in Drug-Handling Molecules10分鐘
**Inside VUMC: The Promise of Personalized Medicine1分鐘
Reading1 個閱讀材料
About this course10分鐘
Quiz1 個練習
Introduction to Personalized Medicine12分鐘
2
完成時間(小時)
完成時間為 2 小時

UNIT 2: STUDYING GENETIC VARIATION

Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing....
Reading
7 個視頻(共 104 分鐘), 1 個測驗
Video7 個視頻
Ancestry: Genetic Variation Across Generations and Geography17分鐘
Finding Disease-Associated Genes: Linkage10分鐘
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1分鐘
Genome-Wide Association25分鐘
Sequencing28分鐘
**Inside VUMC: History of Sequencing Technologies1分鐘
Quiz1 個練習
Studying Genetic Variation12分鐘
3
完成時間(小時)
完成時間為 3 小時

UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1

In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses....
Reading
13 個視頻(共 174 分鐘), 1 個測驗
Video13 個視頻
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16分鐘
Muscle Pains During Statin Therapy (Myopathy)13分鐘
HLA-Mediated Immune Reactions (Skin Rash)9分鐘
Long QT Syndromes, Part 115分鐘
Long QT Syndromes, Part 218分鐘
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4分鐘
A Second Heart Attack a Month After a First15分鐘
Headache During Venlafaxine (Antidepressant)16分鐘
Respiratory Arrest After Tonsillectomy10分鐘
A Bleeding Complication 5 Days After Starting Warfarin21分鐘
**Inside VUMC: Genotyping1分鐘
Drug Metabolism and Variable Drug Responses – Four More Examples17分鐘
Quiz1 個練習
Case Studies, Part I16分鐘
4
完成時間(小時)
完成時間為 2 小時

UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2

Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer. ...
Reading
9 個視頻(共 119 分鐘), 1 個測驗
Video9 個視頻
Marfan Syndrome11分鐘
A Case of Idiopathic Heart Failure16分鐘
Personalizing Care in Neuropsychiatric Disease18分鐘
Personalizing Care in Diabetes21分鐘
Genomics to Subtype Cancer11分鐘
A Family Member With Breast Cancer14分鐘
A Family Member With Colon Cancer11分鐘
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1分鐘
Quiz1 個練習
Case Studies, Part II10分鐘
4.8

熱門審閱

創建者 MTApr 24th 2017

I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.

創建者 CZNov 13th 2016

Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.

講師

Avatar

Dan Roden, M.D.

Professor of Medicine and Pharmacology
Assistant Vice Chancellor for Personalized Medicine

關於 Vanderbilt University

Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees....

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