Learn how advances in biomedicine hold the potential to revolutionize drug development, drug treatments, and disease prevention: where are we now, and what does the future hold? This course will present short primers in genetics and mechanisms underlying variability in drug responses. A series of case studies will be used to illustrate principles of how genetics are being brought to bear on refining diagnoses and on personalizing treatment in rare and common diseases. The ethical and operational issues around how to implement large scale genomic sequencing in clinical practice will be addressed.
提供方
个性化医疗案例研究
范德堡大学
課程信息
15,035 次近期查看
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25%
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25%
加薪或升職
學生職業成果
25%
完成這些課程後已開始新的職業生涯
25%
通過此課程獲得實實在在的工作福利
25%
加薪或升職
可分享的證書
完成後獲得證書
100% 在線
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完成時間大約為15 小時
建議：2-4 hours/week
英語（English）
字幕：英語（English）
教學大綱 - 您將從這門課程中學到什麼
完成時間為 3 小時
UNIT 1: INTRODUCTION TO PERSONALIZED MEDICINE
The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants), as well as review statistical concepts and skills important to clinical data analysis (odds ratios, relative risk, P values, multiple testing, sensitivity, specificity, ROCs). In Module 2 we will explore drug actions and reactions as we look closely at the general mechanisms underlying variability in drug responses, drug metabolism and transport, and genetic variability in drug-handling molecules.
完成時間為 3 小時
11 個視頻 （總計 120 分鐘）, 1 個閱讀材料, 1 個測驗
11 個視頻
Introduction to Personalized Medicine11分鐘
Genetics Definitions, Part I14分鐘
Genetics Definitions, Part II & Types of Genetic Variants15分鐘
Data Analysis, Part I: What is a Good Study?12分鐘
Data Analysis, Part II: What is a Good Test?7分鐘
Introduction to Drug Therapy and General Mechanisms Underlying Variability in Drug Responses13分鐘
Variability in Drug Therapy15分鐘
Drug Metabolism & Transport13分鐘
Genetic Variability in Drug-Handling Molecules10分鐘
**Inside VUMC: The Promise of Personalized Medicine1分鐘
1 個閱讀材料
About this course10分鐘
1 個練習
Introduction to Personalized Medicine12分鐘
完成時間為 2 小時
UNIT 2: STUDYING GENETIC VARIATION
Module 3 focuses on how we study genetic variation. We'll start by looking at families and populations. Topics that will be introduced include family history and inheritance patterns, ancestry, and linkage. Then in Module 4 we shift our focus to studying the contemporary techniques and technologies used to study genetic variation, including genome-wide association and sequencing.
完成時間為 2 小時
7 個視頻 （總計 104 分鐘）
7 個視頻
Ancestry: Genetic Variation Across Generations and Geography17分鐘
Finding Disease-Associated Genes: Linkage10分鐘
**Inside VUMC: From Phenotype to Genotype and Back: Studying Heart Disease in Families1分鐘
Genome-Wide Association25分鐘
Sequencing28分鐘
**Inside VUMC: History of Sequencing Technologies1分鐘
1 個練習
Studying Genetic Variation12分鐘
完成時間為 3 小時
UNIT 3: CASE STUDIES IN PERSONALIZED MEDICINE, PART 1
In Module 5 we will begin to discuss specific cases as these apply to personalized medicine. We will first look very closely at a case of familial hypercholesterolemia as we investigate how we use genomic medicine to move from a rare disease to a common medication, using genomics to find new drug targets, and a discussion of the side effects of statin therapy. In Module 6 we will look at a collection of "high risk pharmacogenetics"cases that illustrate adverse reactions due to drug metabolism and variable drug responses.
完成時間為 3 小時
13 個視頻 （總計 174 分鐘）
13 個視頻
Using Genomics to Find New Drug Targets: Familial Hypercholesterolemia16分鐘
Muscle Pains During Statin Therapy (Myopathy)13分鐘
HLA-Mediated Immune Reactions (Skin Rash)9分鐘
Long QT Syndromes, Part 115分鐘
Long QT Syndromes, Part 218分鐘
**Inside VUMC: Studying Cardiac Arrhythmias in Cells4分鐘
A Second Heart Attack a Month After a First15分鐘
Headache During Venlafaxine (Antidepressant)16分鐘
Respiratory Arrest After Tonsillectomy10分鐘
A Bleeding Complication 5 Days After Starting Warfarin21分鐘
**Inside VUMC: Genotyping1分鐘
Drug Metabolism and Variable Drug Responses – Four More Examples17分鐘
1 個練習
Case Studies, Part I16分鐘
完成時間為 2 小時
UNIT 4: CASE STUDIES IN PERSONALIZED MEDICINE, PART 2
Module 7 continues our focus on case studies with a look at some cases that illustrate how personalized medicine informs treatment decisions related to specific diseases/conditions. These include cystic fibrosis, Marfan syndrome, heart failure, neuropsychiatric diseases, and diabetes. Three cases/lessons focus specifically on how genomic medicine informs testing for and treatment of cancer.
完成時間為 2 小時
9 個視頻 （總計 119 分鐘）
9 個視頻
Cystic Fibrosis11分鐘
Marfan Syndrome11分鐘
A Case of Idiopathic Heart Failure16分鐘
Personalizing Care in Neuropsychiatric Disease18分鐘
Personalizing Care in Diabetes21分鐘
Genomics to Subtype Cancer11分鐘
A Family Member With Breast Cancer14分鐘
A Family Member With Colon Cancer11分鐘
**Inside VUMC: Organizing Infrastructure to Support Genetic Testing Decisions1分鐘
1 個練習
Case Studies, Part II10分鐘
審閱
4.8
來自个性化医疗案例研究的熱門評論
由 VP 提供Feb 16, 2018
This course is not for an amateur. Lots of background knowledge is needed to get full appreciation. This course is from one of the leading centers on genomic medicine and the material reflects this.
由 NJ 提供Apr 8, 2019
The course is very useful for all physicians to diagnoise the disorder and to suggest the solution for their problem and also can explain the cause of the disorder from the root that;s genome.
由 VL 提供Feb 24, 2018
This is a really great course it was very informative, interesting and well structured and I enjoyed the lessons, Prof. Roden did a really great job in this course. Thank you!
由 SP 提供Nov 12, 2019
One of the best courses that I ever completed on coursera. Dr. Dan Roden speaks flawlessly and the way he speaks followed my flow of thoughts and logic. Great course indeed.
由 MT 提供Apr 23, 2017
I learned more about pharmacogenomics and its application, which is crucial for my career development as a young graduate in biology who is pursuing health sciences.
由 NK 提供Jun 13, 2019
This course really helped me understand the precision medicine in terms of genetic variants and its effects on drug metabolism and treatment. Thanks to Prof. Roden
由 CZ 提供Nov 12, 2016
Thank you! I think I'm going to review/re-take this course at least one more time as the lectures are really interesting and insightful.
由 AJ 提供Feb 14, 2016
very informative course at advanced level and also taps the basics required to understand the advanced concepts wherever necessary.
由 MA 提供Dec 1, 2018
Extremely recommended for our medical experts. More than ever, this course encapsulates the medical ideal of personalized medicine.
由 NN 提供Jan 3, 2017
I have been waiting for a course like this and what a great initiative! The instructor language is very accessible and clear.
由 PJ 提供Nov 21, 2016
It was a great course and so much information. I would surely like to get more knowledge and insight of the topic discussed.
由 MS 提供Sep 7, 2019
A really good course to increase your knowledge about individual patient health and their therapy based on their genetics.
由 SS 提供Feb 20, 2016
It was a great learning experience. Would love to do more such courses, if with any specialization in oncology field.
由 SC 提供Jan 11, 2018
Professor was engaging, had a nice speaking voice and the material was presented in a cohesive, analytical way.
由 AA 提供Apr 14, 2019
Very interesting subject. Very useful for the medical professionals as well as those interested on the subject.
由 SW 提供Jun 10, 2016
I like how they interview people who work in the clinic and talk about the applications to real cases
由 SS 提供Jun 18, 2016
Very detailed cases. The instructor discussed each case with in-depth analysis and insights.
由 L 提供Oct 28, 2019
An amazing course, very useful, very informative, so on point and comprehensible.
由 JG 提供Mar 12, 2018
fascinating course but it didn't cover side effects in most pharmaceuticals.
由 KT 提供Jan 26, 2020
Very well presented. Covers relevant and broad range of material.
提供方
范德堡大学
Vanderbilt University, located in Nashville, Tenn., is a private research university and medical center offering a full-range of undergraduate, graduate and professional degrees.
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