課程信息
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Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience. This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam: - Unit 1 Neuroanatomy (weeks 1-2). This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord. - Unit 2 Neural signaling (weeks 3-4). This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity. - Unit 3 Sensory systems (weeks 5-7). Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses. - Unit 4 Motor systems (weeks 8-9). In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement. - Unit 5 Brain Development (week 10). Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life; we will also consider how the brain changes across the lifespan. - Unit 6 Cognition (weeks 11-12). The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future; we will also consider brain systems for maintaining homeostasis and regulating brain state....
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100% 在線課程

立即開始,按照自己的計劃學習。
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Advanced Level

高級

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建議:8 hours/week

完成時間大約為89 小時
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English

字幕:English

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BrainNeurological DisordersNeurobiologyNeurology
Globe

100% 在線課程

立即開始,按照自己的計劃學習。
Calendar

可靈活調整截止日期

根據您的日程表重置截止日期。
Advanced Level

高級

Clock

建議:8 hours/week

完成時間大約為89 小時
Comment Dots

English

字幕:English

教學大綱 - 您將從這門課程中學到什麼

1

章節
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完成時間為 2 小時

Getting Started in Medical Neuroscience

<p>Let's get started in Medical Neuroscience! Each module in Medical Neuroscience will begin with a brief description like this that provides you with an overview of the module. In this first module, you will get to know something about Prof. White and his career in neuroscience; you will understand the scope of Medical Neuroscience, its learning resources, your responsibilities for maximizing your benefit in this course, and you will learn Prof. White's tips on how best to study and learn.</p><p> At the end of this module, please take the ungraded preliminary quiz, "Are you ready for Medical Neuroscience", to self-assess your background knowledge. Your score on this quiz will not count toward your overall score in this course. However, you should be able to pass this quiz (score 70% or better) if you are ready for the academic challenge of this course. Students who are likely to achieve their goals in Medical Neuroscience should be able to successfully answer nearly all of the quiz questions on their first attempt and feel comfortable with assessment questions at this level of knowledge.</p>...
Reading
5 個視頻(共 75 分鐘), 2 個閱讀材料, 1 個測驗
Video5 個視頻
The Scope of Medical Neuroscience11分鐘
Learning resources for Medical Neuroscience32分鐘
Your Part!13分鐘
"Neur-run" with Professor White3分鐘
Reading2 個閱讀材料
Learning Objectives10分鐘
Your Mentor Team10分鐘
Quiz1 個練習
Preliminary Quiz: Are you ready for Medical Neuroscience?22分鐘
Clock
完成時間為 2 小時

Neuroanatomy: Introducing the Human Brain

Your introduction to Medical Neuroscience continues as you experience in this module a brief introduction to the human brain, its component cells, and some basic anatomical conventions for finding your way around the human central nervous system....
Reading
4 個視頻(共 79 分鐘), 1 個閱讀材料, 1 個測驗
Video4 個視頻
Functional Microanatomy of Neurons31分鐘
Non-Neural Cells of the CNS20分鐘
Basic Orientation in the Human CNS7分鐘
Reading1 個閱讀材料
Introduction, Learning Objectives and Recommended Reading10分鐘
Quiz1 個練習
Cells of the CNS and Basic Orientation18分鐘

2

章節
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完成時間為 3 小時

Neuroanatomy: Surface Anatomy of the Human CNS

We now begin in earnest our lessons on neuroanatomy with the surface of the human brain, including a brief run through the cranial nerves and the blood supply to the CNS. In this module, you will learn the basic subdivisions of the vertebrate nervous system; however, your focus should be on the cerebral cortex. Along the way, you will be challenged to "build a digital brain" that should help you generate and improve your mental “model” of the cerebral hemispheres of the human brain. Another great way to refine your mental model is through sketching and crafting, so please do the learning objectives that are designed to help you make visible (and tangible) your understanding of the cerebral hemispheres....
Reading
12 個視頻(共 129 分鐘), 2 個閱讀材料, 2 個測驗
Video12 個視頻
Medial Surface of the Brain5分鐘
Finding the Central Sulcus6分鐘
Ventral Surface of the Brain8分鐘
Building a Digital Brain (Fingers to Gyri)11分鐘
Surface Anatomy of the Brainstem4分鐘
Blood Supply to the Brain15分鐘
Overview of the Cranial Nerves19分鐘
Overview of the Spinal Nerves8分鐘
Localizing the Cranial Nerves13分鐘
Cranial Nerve Function, part 116分鐘
Cranial Nerve Function, part 211分鐘
Reading2 個閱讀材料
Learning Objectives / Recommended Readings10分鐘
Learning Objectives / Recommended Readings10分鐘
Quiz2 個練習
Cerebral Cortex, Brainstem, and Blood Supply24分鐘
Cranial and Spinal Nerves16分鐘
Clock
完成時間為 4 小時

Neuroanatomy: Internal Anatomy of the Human CNS

...
Reading
12 個視頻(共 160 分鐘), 2 個閱讀材料, 2 個測驗
Video12 個視頻
Cranial Nerve Nuclei, part 112分鐘
Cranial Nerve Nuclei, part 219分鐘
Cranial Nerve Nuclei, part 317分鐘
Cranial Nerve Nuclei, part 417分鐘
Internal Anatomy of the Spinal Cord - Gray and White Matter11分鐘
Internal Anatomy of the Spinal Cord -Longitudinal Organization11分鐘
Internal Anatomy of the Spinal Cord In Cross Sections6分鐘
Ventricles8分鐘
Overview of the Internal Capsule and Deep Gray Matter8分鐘
Localizing the Internal Capsule and Deep Gray Matter In Brain Slabs9分鐘
Localizing the Internal Capsule and Deep Gray Matter In Sylvius Atlases12分鐘
Reading2 個閱讀材料
Learning Objectives / Recommended Readings10分鐘
Learning Objectives / Recommended Readings10分鐘
Quiz2 個練習
Brainstem and Spinal Cord22分鐘
Forebrain26分鐘

3

章節
Clock
完成時間為 3 小時

Neural Signaling: Electrical Excitability and Signal Propagation

We now turn our attention from the tangible (human neuroanatomy) to the physiological as we explore the means by which neurons generate, propagate and communicate electrical signals. After exploring those structures in the human brain that are visible to the unaided eye, we must now sharpen our focus and zoom-in, as it were, to the unitary level of organization and function in the central nervous system: to the level of individual neurons and their component parts that are crucial for neural signaling....
Reading
9 個視頻(共 142 分鐘), 1 個閱讀材料, 1 個測驗
Video9 個視頻
Ionic Basis of the Resting Membrane Potential, part 114分鐘
Ionic Basis of the Resting Membrane Potential, part 215分鐘
Ionic Basis of the Action Potential, part 118分鐘
Ionic Basis of the Action Potential, part 212分鐘
Ionic Basis of the Action Potential, part 315分鐘
Molecular Mechanisms of Action Potential Generation, part 120分鐘
Molecular Mechanisms of Action Potential Generation, part 29分鐘
Propagation of Action Potentials20分鐘
Reading1 個閱讀材料
Learning Objectives / Recommended Readings10分鐘
Quiz1 個練習
Generating and Propagating Electrical Signals20分鐘

4

章節
Clock
完成時間為 5 小時

Neural Signaling: Synaptic Transmission and Synaptic Plasticity

Let’s continue our studies of neural signaling by learning about what happens at synaptic junctions, where the terminal ending of one neuron meets a complementary process of another excitable cell....
Reading
13 個視頻(共 226 分鐘), 2 個閱讀材料, 2 個測驗
Video13 個視頻
Synaptic Transmission, part 215分鐘
Neurotransmitters, part 115分鐘
Neurotransmitters, part 222分鐘
Ionotropic Neurotransmitters Receptors, part 117分鐘
Ionotropic Neurotransmitters Receptors, part 211分鐘
Metabotropic Neurotransmitters Receptors and Postsynaptic Mechanisms11分鐘
Synaptic Integration25分鐘
Long-Term Potentiation and Depression, part 122分鐘
Long-Term Potentiation and Depression, part 217分鐘
Long-Term Potentiation and Depression, part 314分鐘
Spike-Timing Dependent synaptic Plasticity19分鐘
Hebb's Postulate11分鐘
Reading2 個閱讀材料
Learning Objectives / Recommended Readings10分鐘
Learning Objectives / Recommended Readings10分鐘
Quiz2 個練習
Synaptic Transmission24分鐘
Synaptic Plasticity18分鐘
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創建者 KRDec 22nd 2016

I have not really taken any Neuroscience courses and I have to say this was very challenging with my already full-time load at school but I did it! Yay! I love Dr. White he is an awesome professor!

創建者 RRNov 25th 2016

While I greatly respect Dr. White's obvious immense knowledge of the neural anatomy, I feel taking this course did very little beyond showing me that perhaps medicine and anatomy wasn't for me.

講師

Leonard E. White, Ph.D.

Associate Professor
Department of Neurology, Department of Neurobiology, Duke University School of Medicine; Department of Psychology & Neuroscience, Trinity College of Arts & Sciences; Director of Education, Duke Institute for Brain Sciences; Duke University

關於 Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

常見問題

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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