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BiologyMicrobiologyPublic HealthVaccine Development

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立即開始,按照自己的計劃學習。

可靈活調整截止日期

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完成時間大約為15 小時

建議:20 hours of videos and quizzes...

英語(English)

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教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 1 小時

Course Introduction

Welcome to Epidemics: the Dynamics of Infectious Diseases. This course will teach you about the variety of parasitic organisms that infect humans, animals, and plants, how these parasites spread through populations, and the various methods that we employ to control them....
3 個閱讀材料
3 個閱讀材料
Course Overview10分鐘
Course Syllabus10分鐘
Glossary of Terms10分鐘
完成時間為 1 小時

Pathogens

In the first module, you will learn about the organisms that can infect us and make us sick: pathogens. We will first take a look at the various types of pathogens that exist, and then learn about what it means to be infectious, and what it means to cause disease. After that, we will cover the various methods by which pathogens can transmit from one person to the next, thereby causing an epidemic. You will learn about the most important number in all of epidemiology, R0, and why this number is so important. Finally, we will learn that microorganisms are not always harmful, but can be beneficial to us as well....
7 個視頻 (總計 40 分鐘), 1 個閱讀材料, 1 個測驗
7 個視頻
Micro and Macro Parasites5分鐘
Infection and Disease6分鐘
Transmission Types4分鐘
Reproductive Number4分鐘
Epidemic Curve6分鐘
Micro-organisms6分鐘
1 個閱讀材料
Module Overview10分鐘
1 個練習
Summative: Pathogens20分鐘
2
完成時間為 1 小時

Hosts

The second module of the course covers host factors that determine the outcome of infection. We will first focus on host immunity and present both the general immune capabilities—the innate immune response—that are encoded in our genes and that provide the initial response to infection and the adaptive immune response, which arises from highly specialized cells that protect against a specific pathogen. You will then learn about the ways that pathogens circumvent these two types of immunity and consider other factors that can contribute to an individual becoming infected or diseased—including genetic factors, other microbes, and how social and emotional factors influence immunity. We will then consider how infection with a microorganism causes disease and how public health officials determine whether a disease outbreak is caused by an infectious organism....
7 個視頻 (總計 41 分鐘), 1 個閱讀材料, 1 個測驗
7 個視頻
Types of Immunity: Adaptive Immune System5分鐘
Immune Evasion6分鐘
Other Determinants of Susceptibility6分鐘
Social Influences on Immunity4分鐘
Pathogens and Disease6分鐘
Detecting an Infectious Disease Outbreak6分鐘
1 個閱讀材料
Module Overview: Hosts10分鐘
1 個練習
Summative: Hosts20分鐘
3
完成時間為 1 小時

Basics of Ecology

The third module of the course covers ecological factors that influence the dynamic patterns of infectious disease. We will discuss the conditions under which a pathogen can drive its host to extinction. We will look at how the demography of the host may allow the pathogen to persist in some populations but not others. We will talk about how host and pathogen characteristics interact to shape different temporal patterns of disease incidence at the population level and discuss the ecological consequences of infecting more than one host species....
9 個視頻 (總計 55 分鐘), 1 個閱讀材料, 1 個測驗
9 個視頻
Force of Infection5分鐘
Cycles4分鐘
Seasonality3分鐘
Flu 19185分鐘
Host Diversity, Host Range3分鐘
Critical Community Size8分鐘
Pathogen-Microbiome Interactions8分鐘
The 2014 Ebola Outbreak9分鐘
1 個閱讀材料
Module Overview: Basics of Ecology10分鐘
1 個練習
Summative: Basics of Ecology20分鐘
4
完成時間為 1 小時

Epidemiology

Where humans live and how they are connected to each other, have strong effects on how infectious diseases can spread. In this module, you will learn about some of the related key concepts of epidemiology. After looking at some fascinating history, we’ll learn about social networks as the ultimate “road map” on which diseases can travel and we’ll talk about how the structure of the network can influence disease dynamics. After that, we’ll cover three topics that all affect infectious disease epidemiology in dramatic ways: human transport systems, population density and so-called superspreaders - individuals who can spread a disease to dozens or even hundreds of other individuals. We’ll close by identifying what information is required for disease surveillance....
8 個視頻 (總計 52 分鐘), 1 個閱讀材料, 1 個測驗
8 個視頻
Social Networks5分鐘
Structure of Networks5分鐘
Superspreaders6分鐘
Spatial Hetergeneity5分鐘
Movement and Modern Transportation5分鐘
Surveillance and Disclosure5分鐘
Co-Infection Consequences10分鐘
1 個閱讀材料
Module Overview: Epidemiology10分鐘
1 個練習
Summative: Epidemiology20分鐘
5
完成時間為 1 小時

Vaccination

In module 5 of the course, you will learn about vaccination, one of the most common approaches to the prevention of epidemics. We'll first put vaccination in the context of the many types of public health interventions that that can be used to prevent or treat disease. After that you will learn about the development of the first vaccine, how vaccines work to prevent infection, and the impact that vaccination has had on the prevention of disease worldwide. After that, you will learn about how vaccination can provide protection to everyone, even the unvaccinated, in the population through "herd immunity" and how we can use the structure of social networks within populations to more efficiently achieve this herd protection. Finally we'll learn about how individuals choices about whether or not to get vaccinated can lead to impacts across the whole of the population....
7 個視頻 (總計 40 分鐘), 1 個閱讀材料, 1 個測驗
7 個視頻
Discovery of the First Vaccine3分鐘
Global Impact of Vaccination6分鐘
How Vaccination Works7分鐘
Herd Immunity5分鐘
Social Networks and Targeted Vaccination6分鐘
Vaccination Refusal5分鐘
1 個閱讀材料
Module Overview: Vaccination10分鐘
1 個練習
Summative: Vaccination20分鐘
6
完成時間為 2 小時

Control Mechanisms

In module 6 of the course, you will learn about mechanisms involved in controlling epidemics. In these lectures, we will discuss what control mechanisms are trying to do, such as breaking the chain of transmission, and many ways by which animals and humans attempt to achieve control. These means include pharmaceutical and non-pharmaceutical interventions, appearing at individual or population levels. We will describe examples of great successes in eradication, and the reasons why control efforts fail....
10 個視頻 (總計 63 分鐘), 1 個閱讀材料, 1 個測驗
10 個視頻
Social Challenges to Eradication4分鐘
Non-pharmaceutical Interventions: Animals5分鐘
Non-pharmaceutical Interventions: Humans 14分鐘
Non-pharmaceutical Interventions: Humans 27分鐘
Behavioral Avoidance6分鐘
Controlling the Vector8分鐘
Consequences of Control7分鐘
Vaccination Ethics7分鐘
New Approaches to an Old Infection5分鐘
1 個閱讀材料
Module Objectives: Control Mechanisms10分鐘
1 個練習
Summative: Control Mechanisms20分鐘
7
完成時間為 1 小時

Emergence

In module 7 of the course, we’ll look at so-called emerging infectious diseases. These are diseases that are causing new problems. They include infectious agents that are new to humanity, but also infectious agents that were once controlled and are now returning, particularly those that are evolving around formerly very effective public health tools like drugs and vaccines. This means much of the week involves a discussion of evolution. We will look at these emerging diseases and ask, where do they come from and what can be done about them? You will learn about new ideas for managing evolution, and some of the societal challenges involved. We will also look at the related question of how some diseases evolve to be nicer or nastier to their hosts....
7 個視頻 (總計 49 分鐘), 1 個閱讀材料, 1 個測驗
7 個視頻
Re-emergence5分鐘
Evolution General5分鐘
Antibiotic and Drug Resistance5分鐘
Management of Resistance8分鐘
Behavioral And Economic Impact5分鐘
Evolution of Virulence8分鐘
1 個閱讀材料
Module Overview: Emergence10分鐘
1 個練習
Summative: Emergence20分鐘
8
完成時間為 1 小時

Global Health

In this final module we explore the global context of epidemics. The world is rapidly changing with the global population increasing and the speed of travel and extent of globalization piling on the pressure of infectious diseases. In this week we set out first to explore a textbook example of disease shaped by the conditions presented by modern living: the disease SARS. We will see how high density living in cities coupled with links to wildlife diseases through markets can create a pandemic. We then explore traditional methods of disease surveillance and then more recent ones afforded to us by the web and networks made possible through google, twitter and other social media. Important to this global view is human behavior, our evolving culture and health. We will also consider emerging disease and the global pattern of diseases across our recent history and how from our earliest beginnings of global travellers we have affected the spread of diseases. Finally, we discuss disease of our food plants and how models of disease spread are developed to promote better global health. As a postscript to the course we ask the questions, so beloved of modern media, could we become zombies?...
9 個視頻 (總計 55 分鐘), 1 個閱讀材料, 1 個測驗
9 個視頻
Disease Surveillance - Classical7分鐘
Disease Surveillance - Digital5分鐘
Culture and Health5分鐘
Emerging Disease Issues7分鐘
Crop Diseases and Food Security5分鐘
Global Pattern of Parasite Biodiversity4分鐘
Models of Infectious Diseases7分鐘
Zombies6分鐘
1 個閱讀材料
Module Overview: Global Health10分鐘
1 個練習
Summative: Global Health20分鐘
完成時間為 4 小時

Ask Us Anything Videos

The videos accessible in this module are responses to questions that have been posed in previous sessions of this course. We invite you to look around here as an additional resource to answer questions you might have yourself or explore topics that pique your interest. ...
36 個視頻 (總計 261 分鐘)
36 個視頻
What Does It Mean to Be Infectious?4分鐘
What is the Impact of Prior Infections on Susceptibility to New Pathogens?5分鐘
What Ended the Plague? What Can We Learn About Pandemics?5分鐘
Can Behavior Contribute to Susceptibility?6分鐘
Marilyn Roosinck and What’s Different about Plant Epidemiology?8分鐘
Can Plants be Vectors of Disease?4分鐘
What are Other Determinants of Susceptibility?5分鐘
Can Pathogens Change Host Function?5分鐘
Immune System Conflict6分鐘
Eric Harvill and What is the Whole Micro-Biome, Pro-Biotic, Good Bacteria Thing?6分鐘
Why Can't Our Antibodies Mutate Like Antigens?4分鐘
How Does Microbiome Exchange Therapy Work?8分鐘
What are the Best Strategies to Combat Multi-Species Infections?7分鐘
How Relevant is the Concept of Critical Community Size?7分鐘
Isabella Catadori and the Translation of Her Lab Work into the Field5分鐘
Examples of Co-Infections and How They Change Epidemiology of Human Infections6分鐘
Super-Shedders v. Super Spreaders and the Pareto Principle6分鐘
The Role of Social Media in Epidemiology and how Information is Disseminated8分鐘
Dr. Vivek Kapur and What Do We Need to Know about Development and Implementation of New Vaccines?9分鐘
Why Don't We Have Vaccines for Everything?8分鐘
Why Don't We Use Targeted Vaccinations?7分鐘
What Are the Benefits of So-Called Gain-of-Function Experiments?11分鐘
Dr. Moriah Szpara and How/Why do viruses like Varicella and Herpes Re-activate Themselves?7分鐘
What are the Challenges to the Eradication of Pathogens and Setting Eradication as a Goal?6分鐘
How Does Stress Affect Susceptibility and the Expression of Disease?6分鐘
Has there been a Collective Change in Human Behavior in Response to Sexually Transmitted Diseases?9分鐘
What can we do to minimize selection for resistance in vectors?8分鐘
Genetic engineering of vectors? pt.17分鐘
Genetic engineering of vectors? pt.27分鐘
What is the role of climate change in disease emergence?8分鐘
What can we learn from antibiotic and vaccine use in agriculture? 7分鐘
Dr. Craig Cameron and What do We Mean by 'Antivirals?'8分鐘
What is it About Polio?9分鐘
What About the One Health Concept?7分鐘
What is the Next Big Thing?8分鐘
4.7
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創建者 DBApr 23rd 2016

Can't fault this course at all and nor would I want to. Very interesting, brilliantly presented and the range of experts really enhanced it. It was engaging and made me keen to find out more.

創建者 DJMay 13th 2017

It is a wonderful course , I have gain and updated my Knowledge in the area of Epidemics and Infectious Disease, Thanks to the Course organizers and most effective presentations . Dr Shivaji

講師

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Dr. Ottar N. Bjornstad

Professor of Entomology and Biology
Department of Biology
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Dr. Rachel A. Smith

Associate Professor
Department of Communication Arts & Sciences and Human Development & Family Studies
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Dr. Mary L. Poss

Professor of Biology
Department of Biology
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Dr. David P. Hughes

Assistant Professor of Entomology and Biology
Department of Biology
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Dr. Peter Hudson

Willaman Professor of Biology
Department of Biology
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Dr. Matthew Ferrari

Assistant Professor of Biology
Department of Biology
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Dr. Andrew Read

Alumni Professor in the Biological Sciences, and Professor of Entomology
Center for Infectious Disease Dynamics
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Dr. Marcel Salathé

Assistant Professor of Biology
Department of Biology

關於 宾夕法尼亚州立大学

Founded in 1855 as Pennsylvania's only land-grant university, The Pennsylvania State University combines academic rigor with a vibrant campus life. A nationally recognized Research-I institution, Penn State teaches students to be leaders with a global perspective. Supporting not only the citizens of our Commonwealth, Penn State engages in collaborative activities with industrial, educational, and agricultural partners in the United States and abroad to generate, disseminate, integrate, and apply knowledge that is valuable to society....

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