Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing.
Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates.
It is divided in 4 modules:
1) Before the transplant
2) The surgical procedures and the challenged patient, including the patient with diabetes
3) Early challenges
4) Late challenges after transplantation.
The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us!
The course is endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS).
This MOOC has been accredited for Continuing Medical Education (CME). Health care professionals who works in the (pre) clinical transplant field, other health care professionals and general practitioners can obtain CME credit at 'LUMC-Boerhaave CME' upon passing the course. For more information we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course
For another interesting course on organ donation and transplantation, see Organ Donation: From Death to Life from Cape Town University https://www.coursera.org/learn/organ-donation
教學大綱 - 您將從這門課程中學到什麼
週
1Welcome to the course
Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. Medical professionals can receive Continuing Medical Education (CME) credit for this course. Information on CME credit and how to obtain credit can be found in our CME credit module. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!
1 個視頻 （總計 2 分鐘）, 9 個閱讀材料
9 個閱讀材料
About us: Introduction to the Team5分鐘
Welcome to Leiden University5分鐘
Complete our short survey10分鐘
Tips for studying online5分鐘
Being successful in an international virtual learning environment5分鐘
Behaving in an academic way5分鐘
CME information10分鐘
How to apply for CME credit10分鐘
CME FAQs10分鐘
Before the Transplant
Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!
11 個視頻 （總計 79 分鐘）, 4 個閱讀材料, 3 個測驗
11 個視頻
The Kidney in Health and Disease5分鐘
Options if Kidneys Fail5分鐘
Immunogenetics7分鐘
Introduction to the Immune System6分鐘
The Humoral Immune System6分鐘
Histocompatibility7分鐘
Cases from Daily Practice - Patient Selection7分鐘
Eurotransplant Company Film 'More than a Match'13分鐘
Interview: Transplant Recipient and Donor: Part 110分鐘
Epitopes6分鐘
4 個閱讀材料
Glossary10分鐘
References5分鐘
HLA Epitope Matching is the Future30分鐘
HLA Antibody Detection: Not All Antibodies are the Same30分鐘
2 個練習
Check your knowledge30分鐘
Check your knowledge10分鐘
週
2The Procedure and the Patient
Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations, 360 virtual reality videos and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module.
14 個視頻 （總計 111 分鐘）, 7 個閱讀材料, 3 個測驗
14 個視頻
Immunological Challenged Patient: ABO Incompatible Transplants6分鐘
Immunological Challenged Patient: Highly Sensitized Patient6分鐘
The Diabetic Patient10分鐘
The Elderly Patient6分鐘
Organ Procurement and Preservation9分鐘
Kidney Transplant Surgery7分鐘
Simultaneous Pancreas Kidney & Islet Transplantation15分鐘
A: Cases from Daily Practice: Different Choices for Different Diabetic Patients5分鐘
B: Cases from Daily Practice: Different Choices for Different Diabetic Patients6分鐘
Interview: Patient with Diabetes14分鐘
Interview: Transplant Recipient and Donor: Part 24分鐘
B Cell Replacement and Diabetes Type II11分鐘
Surgical Challenged Patients6分鐘
7 個閱讀材料
Introduction to Watching 360 VR Videos10分鐘
Serious Game: A Patient with Immunological Challenges30分鐘
Glossary10分鐘
References5分鐘
Highly Sensitized Patients: The AM Program30分鐘
Additional Challenged Transplant Recipients30分鐘
Living Kidney Donation30分鐘
2 個練習
Check your knowledge30分鐘
Check your knowledge20分鐘
週
3Early Challenges in Transplantation
You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!
12 個視頻 （總計 95 分鐘）, 9 個閱讀材料, 3 個測驗
12 個視頻
Surgical Challenges in the Early Period5分鐘
Ischemia Reperfusion Injury6分鐘
Cellular Rejection8分鐘
Antibody Mediated Rejection6分鐘
Immune Suppression10分鐘
Novel Therapeutics: Cell Therapy after Transplantation8分鐘
Cases from Daily Practice A - Patient Cases with Early Challenges6分鐘
Cases from Daily Practice B - Patient Cases with Early Challenges6分鐘
Interview Transplant Recipient & Donor: Part 38分鐘
The Complement System and Transplantation11分鐘
Cases from Daily Practice: Patient Case with an Early Challenge7分鐘
9 個閱讀材料
Serious Game: Interactive Patient Case30分鐘
Optional - Immunesuppressive Regimens and Toxicity Profiles
Biomarkers40分鐘
Therapeutic drug monitoring of immunosuppressive drugs
Glossary10分鐘
References5分鐘
A closer Look at Antibody Mediated Rejection30分鐘
Innate Immunity and Impact on Transplantation30分鐘
Molecular Insights into Cellular Rejection30分鐘
2 個練習
Check your knowledge20分鐘
Check your knowledge10分鐘
週
4Late Challenges in Transplantation
Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module.
12 個視頻 （總計 96 分鐘）, 5 個閱讀材料, 6 個測驗
12 個視頻
Infections: Overview and CMV infection8分鐘
Infections: BK and EBV infection7分鐘
Malignancies8分鐘
Late Challenges after Pancreas and Islet Transplantation8分鐘
Post Transplant Diabetes Mellitus8分鐘
Cardiovascular Disease7分鐘
Tolerance: Interview with Prof. Claas (LUMC) and Prof. Wood (Oxford)13分鐘
Cases from Daily Practice A - Patient Cases with Late Challenges5分鐘
Cases from Daily Practice B - Patient Cases with Late Challenges6分鐘
Recurrence of Kidney Disease after Transplantation8分鐘
Vaccination and Transplantation8分鐘
5 個閱讀材料
Pneumocystis jirovecii10分鐘
Glossary10分鐘
References5分鐘
Skin Diseases after Transplantation and Dermatological Aftercare30分鐘
Tolerance in more Detail30分鐘
5 個練習
Check your knowledge30分鐘
Patient Case 1: Enhanced Glucose after SPK15分鐘
Patient Case 2: Hyperglycemia after Islet Transplantation15分鐘
Patient Case 3: A Complication after Pancreas-alone Transplantation15分鐘
Check your knowledge20分鐘
Final Quiz
We hope you have enjoyed all the modules. Good luck with the final quiz!
If you are interested in an intensive course about transplantation go to the course resources.
2 個閱讀材料, 2 個測驗
2 個閱讀材料
Complete our short survey10分鐘
Leiden Oxford Transplantation Summerschool10分鐘
2 個練習
Final Exam
Final Honours Exam16分鐘
4.8
45 個審閱50%
完成這些課程後已開始新的職業生涯
30%
通過此課程獲得實實在在的工作福利
11%
加薪或升職
熱門審閱
創建者 SW•Dec 27th 2016
Wonderful course. Great instruction on very interesting topics. Videos support learning and a good amount of information every week. Thanks for the organization and delivery of this course.
創建者 AE•May 24th 2017
THE BEST COURSE I have taken in COURSERA\n\nGREAT LECTURERS , BEST VIDEOS, AND VERY ORGANIZED\n\n3D movies are really fantastic\n\nHope to join in future sessions to get better scores
講師
Marlies Reinders
Dr.LUMC, Department of Nephrology and Transplantation
Frans Claas
ProfessorLUMC, Department of Immunohaematology and Blood Transfusion
Cees van Kooten
ProfessorLUMC, Department of Nephrology and Transplantation
Sebastiaan Heidt
Dr.LUMC, Department of Immunohaematology and Blood Transfusion
Volkert Huurman
Dr.LUMC, Department of Transplant Surgery
Hans de Fijter
ProfessorLUMC, Department of Nephrology and Transplantation
Eelco de Koning
ProfessorLUMC, Department of Nephrology and Transplantation and Endocrinology and Metabolism
Andre Baranski
Dr.LUMC, Department of Transplant Surgery
Ton Rabelink
ProfessorLUMC, Department of Nephrology and Transplantation
Aiko de Vries
Dr.LUMC, Department of Nephrology and Transplantation
Jan Nico Bouwes Bavinck
Dr.LUMC, Department of Dermatology
Leo Visser
ProfessorLUMC, Department of Infectious Diseases
Ingeborg Bajema
Dr.LUMC, Department of Pathology
關於 莱顿大学
Leiden University is one of Europe's foremost research universities. This prominent position gives our graduates a leading edge in applying for academic posts and for functions outside academia.
Leiden University is the oldest university in the Netherlands. It was founded in February 1575, as a gift from William of Orange to the citizens of Leiden after they had withstood a long siege by the Spanish. Our motto is: Praesidium Libertatis — Bastion of Liberty.
關於 莱顿大学医学中心
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What are CME credits?
Continuing Medical Education (CME) consists of educational activities that aim to maintain, develop, or increase the knowledge, skills, and professional performance in order to maintain competence and learn about new and developing areas of the medical field. Content for these programs is developed, reviewed, and delivered by faculty who are experts in their individual clinical areas. In various countries, a certain amount of CME-credit hours must be obtained by medical professionals to maintain their licenses.
For this course it is possible to obtain 5, 9 or 13 CME credit points. For more information on how to obtain these points we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course
Can I apply for CME credits if I have already finished the course previously?
Yes, if you have already done the course previously and obtained the Coursera official Course Certificate as proof we encourage you to apply for the CME credits. You can obtain 5 or 9 CME as follows:
1. Sign up for the course at “Boerhaave Continuous Medical Education” (https://www.boerhaavecontinuousmedicaleducation.com/)
2. Upload your Verified Certificate from Coursera (without honors 5 CME or with honors 9 CME). Pay the contribution according to “Boerhaave Continuous Medical Education." They will provide you with the instructions and add the CME credits to GAIA (Dutch participants) and/or provide you with a CME certificate (international participants)
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