Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030.
Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done.
In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
Understanding Cancer Metastasis
提供方
Johns Hopkins University
教學大綱 - 您將從這門課程中學到什麼
週
1History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 個視頻 （總計 18 分鐘）, 1 個測驗
5 個視頻
Introduction to History and Overview of Metastasis48
History and Overview of Metastasis4分鐘
History of Metastasis Theory4分鐘
Introduction to the Sequential Steps of Metastasis5分鐘
1 個練習
History and Overview of Metastasis20分鐘
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 個視頻 （總計 36 分鐘）, 1 個測驗
5 個視頻
Tumor formation: Uncontrolled cell division12分鐘
The role of mutations in primary tumor formation and evolution11分鐘
Neoangiogenesis: new blood vessel formation in cancer5分鐘
The primary tumor microenvironment: what else affects primary tumor growth?6分鐘
1 個練習
Primary Tumor Growth and Neoangiogenesis24分鐘
週
2EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 個視頻 （總計 18 分鐘）, 1 個測驗
4 個視頻
Epithelial-mesenchymal transition, invasion, and intravision9分鐘
Local Tumor Invasion4分鐘
Intravasation2分鐘
1 個練習
Invasion and Intravasation14分鐘
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 個視頻 （總計 31 分鐘）, 1 個測驗
6 個視頻
Glossary of Terms2分鐘
The Circulation4分鐘
How cancer cells survive while in circulation4分鐘
Becoming a circulating tumor cell (CTC) and evading immune detection10分鐘
Homing to a new site in the body and extravasation8分鐘
1 個練習
Survival in the Circulation and Extravasation24分鐘
週
3Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 個視頻 （總計 31 分鐘）, 1 個測驗
6 個視頻
Metastatic homing5分鐘
Evidence for cancer dormancy4分鐘
Cancer dormancy defined8分鐘
Properties of dormant cancer cells6分鐘
Secondary outgrowth4分鐘
1 個練習
Dormancy and Secondary Tumor Growth20分鐘
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 個視頻 （總計 27 分鐘）, 1 個測驗
4 個視頻
Distribution of Metastasis: Where do cancers spread?10分鐘
Cancer Syndromes14分鐘
Congratulations1分鐘
1 個練習
Morbidity and Mortality Associated with Metastasis20分鐘
講師
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of UrologyThe James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Kenneth Valkenburg
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
關於 Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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