關於此課程：Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030. Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done. In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.

此課程適用人群：This course should be helpful to anyone who wants to develop a deeper understanding of cancer metastasis. It should be useful to undergraduate students who are interested in exploring the science of cancer and to health care providers, data managers, and educators who need a more thorough understanding of metastatic cancer and how it affects individuals. The course is NOT designed for patients seeking treatment guidance.

製作方： Johns Hopkins University

教學方： Kenneth J. Pienta, M.D., The Donald S. Coffey Professor of Urology
The James Buchanan Brady Urological Institute
教學方： Jelani Zarif, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
教學方： Sarah Amend, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
教學方： Haley Axelrod, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute
教學方： Kenneth Valkenburg, Prostate Cancer Researcher
The James Buchanan Brady Urological Institute

級別	初級
承諾學習時間	3 weeks, 1.5 hours per week
語言	English
如何通過	通過所有計分作業以完成課程。
用戶評分	4.8 星平均用戶評分 4.8查看學生的留言

授課大綱

第 1 週

History and Overview of Metastasis

In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.

5 個視頻

視頻: Introduction to History and Overview of Metastasis
視頻: History and Overview of Metastasis
視頻: History of Metastasis Theory
視頻: Introduction to the Sequential Steps of Metastasis

已評分: History and Overview of Metastasis

Primary Tumor Growth and Neoangiogenesis

In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.

5 個視頻

視頻: Tumor formation: Uncontrolled cell division
視頻: The role of mutations in primary tumor formation and evolution
視頻: Neoangiogenesis: new blood vessel formation in cancer
視頻: The primary tumor microenvironment: what else affects primary tumor growth?

已評分: Primary Tumor Growth and Neoangiogenesis

第 2 週

EMT / Invasion / Intravasation

During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.

4 個視頻

視頻: Epithelial-mesenchymal transition, invasion, and intravision
視頻: Local Tumor Invasion
視頻: Intravasation

已評分: Invasion and Intravasation

Survival in the Circulation and Extravasation

We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.

6 個視頻

視頻: Glossary of Terms
視頻: The Circulation
視頻: How cancer cells survive while in circulation
視頻: Becoming a circulating tumor cell (CTC) and evading immune detection
視頻: Homing to a new site in the body and extravasation

已評分: Survival in the Circulation and Extravasation

第 3 週

Dormancy and Secondary Tumor Growth

In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.

6 個視頻

視頻: Metastatic homing
視頻: Evidence for cancer dormancy
視頻: Cancer dormancy defined
視頻: Properties of dormant cancer cells
視頻: Secondary outgrowth

已評分: Dormancy and Secondary Tumor Growth

Morbidity and Mortality Associated with Metastasis

In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.

4 個視頻

視頻: Distribution of Metastasis: Where do cancers spread?
視頻: Cancer Syndromes
視頻: Congratulations

已評分: Morbidity and Mortality Associated with Metastasis

常見問題解答

我什麼時候能夠訪問課程視頻和作業？

如果我需要額外的時間來完成課程會怎麼樣？

我支付此課程之後會得到什麼？

我能夠免費學習此課程嗎？

我能夠退款嗎？退款政策是如何規定的？

有助學金嗎？

運作方式

Coursework

Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.

Help from Your Peers

Connect with thousands of other learners and debate ideas, discuss course material, and get help mastering concepts.

Certificates

Earn official recognition for your work, and share your success with friends, colleagues, and employers.

製作方

Johns Hopkins University

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.

價格