Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030.
Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done.
In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
教學大綱 - 您將從這門課程中學到什麼
週
1完成時間為 1 小時
History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 個視頻 （總計 18 分鐘）, 1 個測驗
5 個視頻
Introduction to History and Overview of Metastasis48
History and Overview of Metastasis4分鐘
History of Metastasis Theory4分鐘
Introduction to the Sequential Steps of Metastasis5分鐘
1 個練習
History and Overview of Metastasis20分鐘
完成時間為 1 小時
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 個視頻 （總計 36 分鐘）, 1 個測驗
5 個視頻
Tumor formation: Uncontrolled cell division12分鐘
The role of mutations in primary tumor formation and evolution11分鐘
Neoangiogenesis: new blood vessel formation in cancer5分鐘
The primary tumor microenvironment: what else affects primary tumor growth?6分鐘
1 個練習
Primary Tumor Growth and Neoangiogenesis24分鐘
週
2完成時間為 1 小時
EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 個視頻 （總計 18 分鐘）, 1 個測驗
4 個視頻
Epithelial-mesenchymal transition, invasion, and intravision9分鐘
Local Tumor Invasion4分鐘
Intravasation2分鐘
1 個練習
Invasion and Intravasation14分鐘
完成時間為 1 小時
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 個視頻 （總計 31 分鐘）, 1 個測驗
6 個視頻
Glossary of Terms2分鐘
The Circulation4分鐘
How cancer cells survive while in circulation4分鐘
Becoming a circulating tumor cell (CTC) and evading immune detection10分鐘
Homing to a new site in the body and extravasation8分鐘
1 個練習
Survival in the Circulation and Extravasation24分鐘
週
3完成時間為 1 小時
Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 個視頻 （總計 31 分鐘）, 1 個測驗
6 個視頻
Metastatic homing5分鐘
Evidence for cancer dormancy4分鐘
Cancer dormancy defined8分鐘
Properties of dormant cancer cells6分鐘
Secondary outgrowth4分鐘
1 個練習
Dormancy and Secondary Tumor Growth20分鐘
完成時間為 1 小時
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 個視頻 （總計 27 分鐘）, 1 個測驗
4 個視頻
Distribution of Metastasis: Where do cancers spread?10分鐘
Cancer Syndromes14分鐘
Congratulations1分鐘
1 個練習
Morbidity and Mortality Associated with Metastasis20分鐘
4.8
122 個審閱60%
完成這些課程後已開始新的職業生涯
45%
通過此課程獲得實實在在的工作福利
20%
加薪或升職
熱門審閱
Good course, but why researchers whant to hold/control cancer in a human and not rebuild the destroyed mechanisms of autoregul;ation by genetic engeneering for example? That would be true cure.
It is a beautifully designed course. it never gets boring. The best part is that you can learn at your own pace. Thank you all the instructors and Coursera for making the content available.
講師
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of UrologyThe James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Kenneth Valkenburg
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
關於 约翰霍普金斯大学
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
常見問題
我什么时候能够访问课程视频和作业？
注册以便获得证书后，您将有权访问所有视频、测验和编程作业（如果适用）。只有在您的班次开课之后，才可以提交和审阅同学互评作业。如果您选择在不购买的情况下浏览课程，可能无法访问某些作业。
我购买证书后会得到什么？
您购买证书后，将有权访问所有课程材料，包括评分作业。完成课程后，您的电子课程证书将添加到您的成就页中，您可以通过该页打印您的课程证书或将其添加到您的领英档案中。如果您只想阅读和查看课程内容，可以免费旁听课程。
退款政策是如何规定的？
有助学金吗？
還有其他問題嗎？請訪問 學生幫助中心。
