Learners who complete Science of Exercise will have an improved physiological understanding of how your body responds to exercise, and will be able to identify behaviors, choices, and environments that impact your health and training. You will explore a number of significant adjustments required by your body in order to properly respond to the physical stress of exercise, including changes in carbohydrate, fat and protein metabolism, nutritional considerations, causes of muscle soreness & fatigue, and the effectiveness and dangers of performance enhancing drugs. Active learning assessments will challenge you to apply this new knowledge via nutrition logs, heart rate monitoring, calculations of your total daily caloric expenditure and body mass index (BMI). Finally, learners will examine the scientific evidence for the health benefits of exercise including the prevention and treatment of heart disease, diabetes, cancer, obesity (weight loss), depression, and dementia.
7. Immune System Responses to Exercise
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來自 University of Colorado Boulder 的課程
Science of Exercise
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Physiological Systems During Exercise
In this module you will learn how a number of key physiological systems (muscular, respiratory, cardiovascular, endocrine and immune systems) are regulated during exercise to help maintain homeostasis. These adjustments are critical for exercise to continue for any significant duration. This will include: how the respiratory system adjusts during exercise to ensure proper oxygen delivery and carbon dioxide removal from active muscles; how the cardiovascular system responds to ensure adequate blood flow to various organs, including muscle, during exercise; how the endocrine system plays a major role in regulating key biochemical and physiological responses to exercise and; how exercise influences the immune system and your ability to fight infections.
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Robert Mazzeo, Ph.D.Associate Professor
Department of Integrative Physiology
This video will examine the impact that both a single bout of exercise,
as well as regular training, have on the immune system.
The relatively new field of exercise immunology
has emerged over that past 20 years, and has generated some exciting results.
As the immune system is extremely complex, I will only address some of the key
features as it pertains to exercise and one's susceptibility to infections.
Our bodies are constantly exposed to a number of infectious agents
that could potentially make us ill.
Fortunately, for the most part, our immune system does an excellent job
of neutralizing these pathogens upon exposure.
The two major branches of the immune system are shown here.
They are innate immunity and adaptive immunity.
While exercise will affect both branches,
in the interest of time I will only focus on adaptive immunity.
Adaptive immunity will respond to a specific infectious
agent such as a flu virus.
And make immune cells specifically designed to neutralize and
kill that specific virus.
The two arms of adaptive immunity include both a humoral and cellular component.
For the purpose of this video, the humoral arm is responsible for making specific
antibodies that circulate in the blood, neutralizing infectious agents.
The cellular arm is responsible for
making t-cells that can kill cells that have all ready been infected.
Thus when we look at the responses to exercise, I will discuss the ability to
make both antibodies as well as these T killer cells.
The impact that a single bout of exercise will have on the immune system
will be very much dependent upon the exercise intensity.
A moderate bout of exercise has only a small or
marginal effect on immune function.
However, heavy intense exercise can transiently suppress
immune function up to three hours post-exercise.
Here is one of many studies demonstrating that after an intense part of exercise.
The humoral branch of adaptive immunity and specifically, antibody
production is transiently suppressed at least one hour post exercise.
This study was performed on eight well trained cyclists who exercised for
two hours at 75% of their VOt max.
Shown here is the typical response of the cellular branch
of adaptive immunity to a single bout of intense exercise.
Notice that after an intense training bout of exercise
these marathon runners demonstrated a significant reduction
in their ability to produce T-cells up to three hours after exercise.
Again, this immunosuppression was transit as T-cell production returned
to normal after six hours.
Taking together the suppression in both humoral and cellular immunity
immediately post exercise has lead to the Open Window Theory.
Basically, this theory states that for several hours after an intense
bought of exercise your immune system is transitory suppressed.
Giving any opportunistic bacterial or
virus the chance to get a foot hold leading to infection.
You may have already been exposed to these infectious agent before the bout of
exercise, but your immune system was effectively neutralizing them prior to
the intense bout of exercise.
Thus, one's susceptibility to infection is likely greater during the post
exercise recovery period.
Possible mechanisms for this transient suppression in immune function
after exercise center around the elevation of several stress hormones.
These include the adrenal hormones of cortisol, epinephrine, and
norepinephrine, which are known to be immunosuppressive.
Additionally, an increase in body temperature as occurs during exercise
may also play a role in immunosuppression.
Shown here is the cortisol and
epinephrine response from those marathon runners described earlier in this video.
You'll had a significant reduction in T-cell production
three hours after a bath of intense training.
Noticed that both cortisol and epinephrine levels remained elevated
when compared to rest for several hours into the recovery period.
So does this transient suppression and
immune function actually translate into an increase susceptibility to infection?
The answer appears to be yes.
For the weeks following a big racing competition such as a marathon,
Iron Man, or Tour de France,
the incidents of infection is two to five fold greater an athletes who completed.
When compared to individuals of similar fitness, that did not compete.
Shown here is just one of many studies that demonstrates this point.
Runners who competed in a 56-kilometer race had a two and
a half-fold increase in contracting upper respiratory tract infection,
when compared to their roommates.
As their roommates were exposed to the same possible environmental infectious
agents, this suggests that it was the bout of intense exercise that made
the runners more susceptible to infection.
Other factors that can contribute to an increased susceptibility to infection
are shown here.
I will briefly discuss the interaction between exercise and
stress at the end of this video.
People frequently ask me if they should exercise when they're sick.
Some people believe that the work out will kill any bacteria or
viruses and rid the body of toxins.
This is absolutely false.
In fact, as stated above, a single bout of exercise can suppress immune function
during the post-exercise recovery period, thus making the matter worse.
The general rule of thumb is not to exercise,
but rest if your symptoms are below the neck.
Such as muscle aches, fever, an upset stomach, and lung congestion.
If you have symptoms above the neck, such as a simple head cold,
it is generally okay to engage in light easy exercise as tolerated.
However, if you find even easy exercise makes you feel worse,
then you should stop exercising and rest until you have recovered.
As you start to feel better,
you can gradually return to your normal exercise pattern.
Now let's examine how a training can influence your baseline immune function.
The majority of studies clearly indicate that participation in regular
moderate physical activity will improve overall immunity.
Again, I will show you just one representative study of many
demonstrating this outcome.
In this study, three months of walking in previously sedentary individuals
reduced the incidence of upper respiratory track infections by approximately 50%.
Over a 15 week window of observation.
The mechanisms responsible for this training adaptation remain to be
determined, but likely involve both branches of the immune system.
While moderate training can boost immune function,
involvement in repeated high intensity training will have the opposite effect.
As I've already stated in this video,
a single bout of high intensity exercise is immunosuppressive.
Frequent engagement in these types of training sessions will chronically
suppress immune function, making the individual more susceptible to infections.
As shown here, this can result in a weakened immune system
that puts the individual at a greater risk for infection.
Even when compared to their sedentary counterparts.
The frequency of infections is a common complaint among many distance athletes.
In fact, one of the classic symptoms of overtraining in athletes is an increase
in the number of infections resulting from a chronically suppressed immune system.
Finally, I would like to discuss the interaction of stress, immune function and
regular exercise.
It is well established that repeated or
chronic stress can weaken the immune system.
And can contribute to the onset of illness and disease.
Here is just one example demonstrating that regular participation
in moderate exercise can reduce the negative effects of other life stressors
on the immune system.
When sedentary animals are exposed to a stressor,
their ability to mount an effective immune response is clearly blunted.
However, endurance trained animals when exposed to the exact same stressor,
show no reduction or impairment in immune function.
Similar findings have been found in humans.
Basically moderate exercise training can provide a degree of immune resilience, or
stress resistance, protecting you from the adverse affects of other life stressors.
In summary, a single bout of high-intensity exercise can
transiently suppress immune function allowing an opportunistic virus or
bacteria to make you ill.
Participation in regular moderate exercise can improve baseline immune function,
thereby, lowering the risk of infection.
Chronic high-intensity training and overtraining can lower immune function,
thereby increasing the rest risk of infection.
Regular moderate exercise can reduce the negative effects of other life
stressors on the immune system and, thus, your susceptibility to infections.
