In this module we will introduce you to a quality improvement project that was built following successful implementation of the Central Line Associated Blood Stream Infection program developed and implemented at Johns Hopkins. The learner will see that building momentum from a previous success is possible using proven quality Improvement bundles and the results of the adaptive work using the Comprehensive Unit-Based Safety Program to improve unit based culture. The learner will understand the rigorous preparation and tool development needed to support clinicians when you move a program to another venue. They will develop an understanding of the Collaborative approach that includes on-boarding or immersion into the content, allowing preparation time and providing both content and coaching call that support the teams implementing the initiative. Learners will see how to utilize the CUSP program to meet adaptive challenges. Learners will also see the tool-kit that was developed including the documents necessary to provide support for front line clinicians that we believed necessary for a successful quality improvement and patient safety program.