Chevron Left
返回到 系统生物学导论

學生對 西奈山伊坎医学院 提供的 系统生物学导论 的評價和反饋

423 個評分
90 條評論


This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems? The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses....



Feb 07, 2016

Very useful course in order to learn the basics in systems biology. You only need some training in biology to understand the concepts but the course is easy to follow and very complete.


Aug 08, 2019

Great foundational material and insights from Prof. Iyengar that supports the 'disruptive' trends underway at the intersection of Computational Biology and Medicine.


1 - 系统生物学导论 的 25 個評論(共 88 個)

創建者 Himanshu

Feb 21, 2019

Although I am thankful to the Icahn School of Medicine at Mount Sinai, Ravi Iyengar & colleagues and especially Coursera for providing the such courses online,

I have to say after taking this course that I did not find this helpful and would not really recommend it to anyone. The course is sort of a bird's eye view of the field of systems biology such that a beginner would not understand much of anything and an experienced researcher would also not really benefit from it either. In my view the course is sort of a "Review of certain handpicked literature" and it does not Explain well the basic concepts of system biology.

創建者 Karel B

Dec 16, 2015

The lecture quality should be dramatically improved. Even at 2x speed, I feel Iyengar should further practice is presentation and redo the videos. In the conclusion, Iyengar states that no textbooks are available for the field because it is "new", but an Amazon search shows several seem to exist, and many of the studies referenced in this course are years old, even more than a decade in some cases... so I think better materials for more organized slides must exist. I've taken more than 5 coursera classes, and this has been my least satisfying. ... I do appreciate the introduction this provided, for free, and plan to keep learning in this space, though not in this course sequence.

創建者 Radu A

Apr 21, 2019

Tests do not reflect course information. Even if the title is "introduction" it asumes the user is familiar with a lot of topics. It is probably good for people that just need a reminder of something that they studied previousely.

They teach basic theory and then require the student to know much more on exams. Maybe this course should be done last in the specialization. (I'm hoping the others are better)

創建者 Erick C O

Feb 07, 2016

Nice course, a little boring at the beginning with so much data about cell signaling, (kinases names, and specific routes).

創建者 William N

Jun 18, 2019

This is a good course, overall - it starts off with a lot of technical detail about network, but I honestly encourage anyone to keep going with it as the second half of the course is full of really interesting material on signalling networks and modelling, and having finished it, I certainly feel much more informed. However, the assessments can be tricky - they often require rote learning of specific detail from the lectures (often, detail which isn't highlighted a particularly important). They also occasionally involve difficult to understand questions, and several questions have had spelling or grammatical errors.

However, overall, I'd recommend this if you have previous undergraduate education in molecular biology, and a general understanding of how cell biological systems work.

創建者 Daniel P

Sep 05, 2018

This course is difficult. Often very difficult. Sometimes extremely difficult. However, the assessments are reasonably accessible for someone who is not highly experienced in the relevant fields (i.e molecular biology, biochemistry or mathematical modelling). I enjoyed the course tremendously. The content of the course was stellar, and delivered to me exactly what I was hoping for from this course. When I first began the course I was quite surprised at the level of detail (this is my first time using Coursera, and I had thought the course would be a lot more "fluffy" or "wishy-washy" than it was). The level of detail was paired (almost always) with a description by Ravi Iyengar which was simple and captured the main "take-home" points. This I imagine is only possible thanks to the eminence and experience of Dr Iyengar and the hard-work by the rest of the team behind the scenes. Many aspects can be a little daunting (I did not understand anything with great deepness, I often did not understand things very much, but I rarely did not understand things at all - thanks to the emphasis on take-home points). I think an essential course for anyone who wants a taste of all things systems and networks.

創建者 Christopher O

May 28, 2017

An excellent introduction to Systems Biology. I studied electrical engineering for undergrad and neglected to take more than the single biology course that was required, so I was a little unsure of how the course would go. There are actually many parallels with systems biology and engineering, so most of the material was intuitive or could be easily fitted with my previous knowledge. I had to spend additional time for nomenclature and rechecking exam questions to make sense of the answers, but the class is organized in a way that you can actually acquire the information you need to build a foundation and be able to consider what researchers from various backgrounds are concerned with.

創建者 Oscar W

Dec 02, 2018

A good introduction to this topic for sure. As others have said, this is perhaps more like an "advanced" course than intermediate (I already have a masters in biochemistry and a lot of programming experience) but for me it's perfect. He does talk slowly though so I've been increasing the play speed to 1.5x

創建者 Raul G

Mar 18, 2019

An exceptional course for anyone interested in the area of bioinformatics, cell biology, biotechnology, etc. I think it is very valuable to have some background in molecular biology but if you are interested, do not doubt to take it.

創建者 Sumin W

Jun 01, 2016

The required readings are stellar. I didn't know all this stuff, and there's a real open-source philosophy. The bio stuff is challenging for an engineer like myself, but worth Googling and learning in the long run

創建者 Jonathan R

May 03, 2018

It's a challenging subject. Don't expect to walk away from the course with a complete grasp of systems biology. However, this course is a fantastic place to start.

創建者 Daren E

May 07, 2017

Very nice course, would have liked more interactivity / problem solving type questions

創建者 Ghaleb M M

Jun 06, 2017

The lecturer is bad at communicating , The material is hard to understand , and he skims through the contents , The Quizzes are not related to the materials sometimes

Solution : No doubt that the lecturer is a distinguished person , but this kind of material should be taught by a young faculty member that can communicate much better with the students , the current lecturer can supervise the material and answer questions in the discussion boards

創建者 Paul G

Apr 03, 2020

Having completed somewhere in the region of 70 online courses I can say with complete honesty that "Introduction to Systems Biology" is the worst online course I have ever taken. The videos are a rambling sprawl with little coherence and are in need of serious editing. The amount of prior knowledge assumed is absurd for a course of this scope - and comments in the discussion forums seems to indicate that many others feel the same. In over 4 years since the course first started, there has not been a single post by the instructor and the lecture notes are as equally muddled as the lecture viedos. In all honesty, a prospective student would be better off buying one of the many excellent monographs on Systems Biology and taking a random page at KEGG and studying that. Frustrating and did not in any way meet my objective of gaining a good grounding in Systems Biology.

創建者 Adam G C

Dec 30, 2019

Given the constraints of the MOOC format, Professor Iyengar and his lab did an excellent job of presenting an introduction to this complex and still-developing field.

Ultimately, systems biology is more something that you do than something that you know about just from reading about it, but a course like this can serve as a jumping-off point for finding particular areas that interest you enough that you will put in the time and work to gain hands-on experience.

A minor complaint: The last question on the last lesson quiz (not the final) is a broad philosophical question, and several of the answer choices are defensible. The supposedly correct answer choice is one of the less reasonable ones. I would go into further detail, but it may not be appropriate to give away the answer here.

創建者 Sajid A

Feb 15, 2017

This is a great platform to learn such complex topics broken down into small segments which helps to absorb and apply the knowledge in our respected work fields.I am very optimistic to complete all 6 of the course and by then I will actually learn some valuable things which I can apply in my own field of work.

創建者 Cristiano C

May 11, 2020

Excellent introductory course. Professor Ravi Iyengar is very clear and has a broad knowledge of Systems Biology. Indicated papers help to understand the topics and allow the student to have a good starting point in each topic. Thanks all the team for the excellent course.

創建者 Fabián H

Aug 30, 2020

This is a very complete introduction to Systems Biology, I felt that I aquire relevant knowledge to undertake further courses on the subjetct. Hoever, the learning curve could have been less steep in this introductory course.

創建者 Samuel M V

Feb 07, 2016

Very useful course in order to learn the basics in systems biology. You only need some training in biology to understand the concepts but the course is easy to follow and very complete.

創建者 李俊宏

Aug 30, 2017

It's really a nice introduction of system biology. I have learned a lot of new ideas.

Professor Iyengar is quite interesting! Still I hope more mathematical details can be included!

創建者 Rene R I

Jan 16, 2016

Great course! It explains very generally but clearly all different aspects involved in Systems Biology. The material used is good and so are the articles used for learning.

創建者 Balu R

Aug 08, 2019

Great foundational material and insights from Prof. Iyengar that supports the 'disruptive' trends underway at the intersection of Computational Biology and Medicine.

創建者 Ganeshan J

Jul 07, 2020

Really helpful in both gaining confidence and knowledge! Such a wonderful online platform to expand our knowledge in our field of interest

創建者 Cristina B

May 03, 2020

excellent introduction by one of the most outstanding expert in the field, Prof Iyengar

many thanks from Cristina , Milan , Italy

創建者 Lun X

Jul 20, 2016

Ravi is a great researcher. This class is taught with great clarity and expertise. Subtitle is much less impressive though.