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4.8
673 個評分
182 個審閱
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完成時間(小時)

完成時間大約為31 小時

建議:16 hours...
可選語言

英語(English)

字幕:英語(English)...
100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
完成時間(小時)

完成時間大約為31 小時

建議:16 hours...
可選語言

英語(English)

字幕:英語(English)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 2 小時

Brain Excitements for the 21st Century

Welcome to synapses, neurons and brains!...
Reading
8 個視頻(共 74 分鐘), 5 個閱讀材料
Video8 個視頻
Welcome Words and Great Thinkers9分鐘
The Blossoming of the Brain in the World7分鐘
The Connectomics10分鐘
Brainbow8分鐘
Brain Machine Interface BMI16分鐘
Optogenetics7分鐘
Simulation of the Brain - Blue Brain Project8分鐘
Reading5 個閱讀材料
About the Course10分鐘
Course Staff10分鐘
Course Information10分鐘
How to Use Discussion Forums10分鐘
Lecture Slides10分鐘
2
完成時間(小時)
完成時間為 2 小時

The Materialistic Mind - Your Brain's Ingredients

This module's purpose is to acquaint you with "The materialistic mind – your brain’s ingredients". You will become intimately acquainted with the beauty and variety of neurons – the elementary building block/microchips of the brain. We will highlight a big controversy between two great anatomists (Ramon y Cajal and Camillo Golgi) who both received the Nobel Prize in 1906. They asked whether the neuron is a separate “independent” unit (like other cells in other tissues) or whether it is part of a continuum? We will next discuss the neuron as an input-output device and highlight a key property of the nervous system, namely that neurons connect to each other via a wonderful devise called “synapse”....
Reading
8 個視頻(共 82 分鐘), 1 個閱讀材料, 1 個測驗
Video8 個視頻
The Neuron9分鐘
The Neuron Doctrine9分鐘
The Neuron as I/O Device Part I8分鐘
The Axon14分鐘
The Dendrite8分鐘
Neuron Type11分鐘
The Synapse14分鐘
The Neuron as I/O Device Part II7分鐘
Reading1 個閱讀材料
Lecture Slides10分鐘
Quiz1 個練習
Brain Excitements for the 21st Century and The Materialistic Mind28分鐘
3
完成時間(小時)
完成時間為 2 小時

Electrifying Brains –Passive Electrical Signals

In this module we will discuss the "Electrifying brain – passive electrical signals". We will show that neurons are electrical device and learn what enables neurons to become “electrifying”. Here we will describe only the passive (vs. active) electrical properties of neurons. We will show that, at the quiescent state, the difference in electric potential across the cell’s membrane is always negative inside the cell (“the “resting potential”); we next show that the membrane behaves like an electrical (resistance-capacitance) RC circuit and highlight the notion of “membrane time constant” and, consequently, the ability of neurons to summate (in time) successive (synaptic) inputs (“electrical memory”) – a fundamental mechanism utilized by the brain. We will also show that when the synapse is activated, it generates an analog electrical signal (“the post-synaptic potential”, PSP) in the receiving (“post-synaptic”) cell. Most interestingly, there are two types of synapses in the brain – “excitatory” and “inhibitory” – we will discuss how these two opposing signals interact in the receiving ``neuron. This module is more technical than the more descriptive first two lessons; we encourage those of you who are not familiar with basic electricity (resistance, capacitance, Ohms law and Kirchoff’s law) to read about these in the sources links for this week’s lecture....
Reading
11 個視頻(共 105 分鐘), 1 個閱讀材料, 1 個測驗
Video11 個視頻
The Voltage Equation for the Passive Cell9分鐘
The Membrane Time Constant14分鐘
Temporal Summation9分鐘
The Resting Potential8分鐘
The Synaptic Potential Part 19分鐘
The Synaptic Conductance6分鐘
The Synaptic Battery10分鐘
The Synaptic Potential Part 28分鐘
The Voltage Equation for the Synapse and EPSP and IPSP13分鐘
Summary3分鐘
Reading1 個閱讀材料
Sources for Lesson 310分鐘
Quiz1 個練習
Electrifying Brains –Passive Electrical Signals22分鐘
4
完成時間(小時)
完成時間為 2 小時

Electrifying Brains – Active Electrical Spikes

In this module we are covering "Electrifying brains – active electrical spikes". In the previous module we learned that: 1-neurons are electrical devices, 2 - that the membrane behaves as an RC circuit, 3 - that synapses operate by opening a new cross-membrane conductance attached with a battery. In the present module we will proceed to deal with the active electrical aspects of neurons. Synaptic inputs are the elementary (input) sources to neurons and, typically, many (excitatory) of them are required to summate (“temporal summation”) to generate a highly (“all or none”) output signal – the notorious spike (or “action potential”). In our current understanding, sensory, motor, emotional, etc., information is represented by a particular set of neurons that “fire” these spikes. So no movies or music in your brain only spikes representing (coding for) these movies and music. We will focus on the membrane mechanisms underlying the generation of the spike and in particular on the model of Hodgkin & Huxley for the spike which is probably the most fundamental and beautiful model in neuroscience. Hodgkin & Huxley received the Nobel Prize in 1963. ...
Reading
5 個視頻(共 80 分鐘), 1 個閱讀材料, 1 個測驗
Video5 個視頻
The All or None Spike and the Voltage Clamp11分鐘
Membrane Currents Underlying the Spike14分鐘
Modeling the Membrane Currents14分鐘
The H&H Spike Model24分鐘
Reading1 個閱讀材料
Lecture Slides10分鐘
Quiz1 個練習
Electrifying Brains – Active Electrical Spikes26分鐘
4.8
182 個審閱Chevron Right
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83%

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創建者 AAug 14th 2017

Excellent teaching by Sir. He has created one more enthusiast in the journey of decoding Human Brain. Thank you Sir, getting my basics clear and this will help me to be better Neuro/AI researcher.

創建者 DDSep 18th 2015

It is a very interesting and well-done course about neurobiology. Prof. Sedev has many interactive tasks and he tries to explain details as easy as possible. All in all it is understandable.

講師

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Idan Segev

Professor
Computational Neuroscience

關於 Hebrew University of Jerusalem

Ranked among the top academic and research institutions worldwide, the Hebrew University of Jerusalem is Israel's leading university and premier research institution. Serving 23,000 students from 70 countries, the Hebrew University produces a third of Israel’s civilian research and is ranked 12th worldwide in biotechnology patent filings and commercial development. The Hebrew University was founded in 1918 by visionaries including Albert Einstein, Sigmund Freud, Martin Buber and Chaim Weizmann. It is located on three campuses in Jerusalem and a fourth in Rehovot. Visit the website at http://new.huji.ac.il/en. Join our online learners community at https://www.facebook.com/groups/hujimooc/. ...

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