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初級

完成時間大約為13 小時

建議:6 hours/week...

英語(English)

字幕:英語(English)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 2 小時

Enzymes, Enzyme Discovery and Engineering

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics.

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8 個視頻 (總計 61 分鐘), 2 個閱讀材料, 1 個測驗
8 個視頻
Introduction from Nigel Scrutton38
Overview and introduction9分鐘
How do enzymes work?15分鐘
How do we discover enzymes for application in biotechnology?5分鐘
How can we study and characterise the catalytic activity of enzymes?7分鐘
Engineering Enzymes I: Directed Evolution8分鐘
Engineering Enzymes II: Rational Design of Biocatalysts11分鐘
2 個閱讀材料
Pre Course Survey and Course Credits10分鐘
Glossary10分鐘
1 個練習
Enzymes, Enzyme Discovery and Engineering22分鐘
2
完成時間為 2 小時

Methods in Systems and Synthetic Biology

Recent advances in our ability to read and write genome sequences on a large scale have led to an ambitious vision for a new generation of biotechnology, often referred to as Synthetic Biology. Synthetic Biology aims at turning biology into an engineering discipline, in which organism engineers use computational tools to design biological systems with novel valuable functionalities, which are then built using advanced high-throughput genetic engineering, and tested by rapid screening technologies that collect diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle. This module will introduce the engineering concepts that inform Synthetic Biology and the cutting-edge technologies that underlie our dramatically increasing ability to construct living systems with custom-made functionalities. All stages of the design-build-test cycle for novel biosystems will be discussed, with a special focus on their integration in a unified bioengineering platform. Examples will focus on the application of Synthetic Biology as an enabling technology for the bioindustry, especially for the improved microbial production of high-value chemicals and drugs. A section on responsible research and innovation will explore the transformative potential of this innovative technology within a broader socio-economic context, creating awareness of the ethical and political implications of research in this field.

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9 個視頻 (總計 61 分鐘), 2 個閱讀材料, 1 個測驗
9 個視頻
Introduction to Synthetic Biology: Visions for Biotechnology 2.06分鐘
Designing biological systems: Computational modelling and systems biology9分鐘
Building biological systems I: Genome synthesis and genome editing9分鐘
Controlling and engineering pathways in Synthetic Biology9分鐘
Testing Biological Systems Biological debugging using metabolomics8分鐘
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics I5分鐘
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics II6分鐘
Conclusions and Outlook Systems and Synthetic Biology6分鐘
2 個閱讀材料
Glossary10分鐘
Systems and Synthetic Biology10分鐘
1 個練習
Methods in Systems and Synthetic Biology22分鐘
3
完成時間為 2 小時

Biochemical and Bioprocess Engineering

Biochemical and bioprocess engineering is concerned with the design of processes which involve biological transformations to manufacture a range of bio-based chemicals, biopharmaceuticals and biofuels. Through applying knowledge of process constraints, which are usually described mathematically, biochemical engineers are able to design a series of integrated process steps or “unit operations” which together make up a bioprocess. This module will give an appreciation of the key role biochemical engineering has in translating discoveries coming from life sciences and synthetic biology, such as improved microbial platforms for product expression, into economically viable full scale production processes. Key engineering concepts and the problem solving approach required for the design of bioprocesses will be taught by a group of biochemical engineers from The University of Manchester, University College London and Technical University of Denmark.

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8 個視頻 (總計 90 分鐘), 1 個測驗
8 個視頻
Introduction from James Lawrence and Michael Sulu45
Introduction to Biochemical and Bioprocess Engineering12分鐘
Microbial fermentation processes and bioreactor design10分鐘
Biocatalysis and enzymatic processes24分鐘
Recovery and purification of small molecules11分鐘
Recovery and purification of large molecules9分鐘
Process economics and scale-up19分鐘
1 個練習
Biochemical and Bioprocess Engineering24分鐘
4
完成時間為 2 小時

Pharmaceuticals and Fine Chemicals

This module looks at the production of pharmaceuticals and fine chemicals using biocatalysis. Specifically, we will look at isolated biocatalytic transformations using isolated enzymes or whole cells as catalysts to manufacture commercially important products including pharmaceuticals, industrial monomers and personal care products. This module will be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership dedicated to the development of manufacturing sustainable pharmaceuticals led by The University of Manchester and the pharmaceutical company GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The University of York, will look at six industrial examples of biocatalytic reactions involving six different enzyme transformations. Each example will look at the product, manufacturing route, mechanism of the enzyme reaction and some of the sustainability drivers and metrics for adopting IB as part of the manufacturing route. Over the six examples, a number of key attributes of enzyme catalysed processes that need to be considered for successful scale-up will be examined. These include choice of free enzyme or whole cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Each example will have a number of references to the primary literature covering the product and enzyme type for further learning outside of the module.

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7 個視頻 (總計 66 分鐘), 2 個閱讀材料, 1 個測驗
7 個視頻
Industrial Example 1: Hydrolases11分鐘
Industrial Example 2: Transaminase11分鐘
Industrial Example 3: DERA Aldolase10分鐘
Industrial Example 4: Alcohol Dehydrogenases12分鐘
Industrial Example 5: Nitrile Hydratases8分鐘
Industrial Example 6: Amino Acid Oxidases9分鐘
2 個閱讀材料
CHEM2110分鐘
References and Further Reading10分鐘
1 個練習
Pharmaceuticals and Fine Chemicals24分鐘
5
完成時間為 2 小時

Case Studies: Bioenergy and Biomaterials

Bioenergy is renewable energy extracted from biomass (organic biological material such as plants and animals, wood, waste, (hydrogen) gas, and alcohol fuels. Biomass is the fuel, bioenergy is the energy contained within that fuel. In this module we will look at biofuel production and the research and knowledge challenges associated with increasing the contribution of UK bioenergy to meet strategic environmental targets in a coherent, sustainable and cost-effective manner. In addition, we will be looking at biomaterials science and, in particular, the development of novel biomaterials and their application in a variety of industrial and medical products. Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite materials. As a science it is around 50 years old so we will be considering the current trends and the future of biomaterials research and biomanufacturing technologies.

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7 個視頻 (總計 80 分鐘), 2 個閱讀材料, 1 個測驗
7 個視頻
The challenges of sustainable bioenergy development12分鐘
New routes to biofuel production18分鐘
Membrane processes in industrial biotechnology13分鐘
Enzymatic biofuel cells11分鐘
Biomaterials: engineering cell niches hydrogels14分鐘
Biomanufacturing8分鐘
2 個閱讀材料
Reading List10分鐘
Glossary10分鐘
1 個練習
Case Studies: Bioenergy and Biomaterials24分鐘
6
完成時間為 2 小時

Case Studies: Glycoscience and Biotherapeutics

Glycoscience is the science and technology of carbohydrates, which are the most abundant biological molecules on Earth and make up part of the biology of all living organisms. This module will introduce the fundamental concepts of glycoscience, leading onto the benefits for society and how this drives and impacts the bioeconomy. A series of case studies will be used to present some of the key challenges and glycan-based solutions in pharmaceuticals and personalised medicine, food security and biomaterials. Biopharmaceuticals are new medicines that are made biologically. “Biologically” means that the production is too complex for simple chemistry and that we currently have to direct biological materials – cells, using the spectrum of natural catalytic reactions - to make these revolutionary medicines. We will be looking at the revolution in these development medicines within a clinical, societal and economic context and the approaches used to ensure production of safe and effective biopharmaceuticals, using various types of expression systems. Students will be introduced to detailed case studies that illustrate how the principles developed in other sub-modules are put into practice in the industrial context.

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8 個視頻 (總計 71 分鐘), 1 個測驗
8 個視頻
Introduction from Alan Dickson1分鐘
Introduction to glycoscience4分鐘
Glycoscience: pharmaceuticals & personalised medicines9分鐘
Glycoscience: other applications11分鐘
Biopharmaceuticals: the clinical significance10分鐘
Biopharmaceuticals: the technical stuff15分鐘
Biopharmaceuticals: the industrial perspective15分鐘
1 個練習
Glycoscience26分鐘
4.7
50 個審閱Chevron Right

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來自Industrial Biotechnology的熱門評論

創建者 JQAug 7th 2017

I really enjoyed this course and although I am not a chemist nor a research biotech guy, I am a dentist that enjoyed the opportunity to learn more about industrial biotechnology. Thanks so much!

創建者 MBJan 28th 2018

Awesome intro to modern technologies and production processes used in the Biotech Industry! Does a great job of detailing where the industry is headed in the upcoming years.

講師

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Prof. Nicholas Turner

Deputy Director
Manchester Institute of Biotechnology
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Prof. Nigel Scrutton

Director
Manchester Institute of Biotechnology

關於 曼彻斯特大学

Tracing its roots back to 1824, the University of Manchester is home to almost 40,000 students. The University has three Nobel laureates among its current staff – more than any other British university - and a total of 25 Nobel laureates have come from our past and present students and staff. We have three main goals: to undertake world-class research; to deliver an outstanding learning and student experience; and to be socially responsible....

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