關於此課程：In this culminating project, you will deploy the tools and techniques that you've mastered over the course of the specialization. You'll work with a real data set to perform analyses and prepare a report of your findings.
製作方： Johns Hopkins University
教學方： Jeff Leek, PhD, Associate Professor, Biostatistics
Bloomberg School of Public Health教學方： Kasper Daniel Hansen, PhD, Assistant Professor, Biostatistics and Genetic Medicine
Bloomberg School of Public Health
| 基本信息 | 課程 8（共 8 門，基因组数据科学 Specialization ） |
| 承諾學習時間 | 8 weeks of study, 2-4 hours/week |
| 語言 | English |
| 如何通過 | 通過所有計分作業以完成課程。 |
| 用戶評分 |
授課大綱
第 1 週
Introduction
In this first week, we'll introduce the project and get you oriented to the tasks that you'll be performing over the next several weeks.
1 個視頻, 6 個閱讀材料
- Reading: Welcome
- Reading: The big question
- Reading: What you will be doing in this capstone project
- Reading: Passing the Capstone
- Reading: Why re-analysis?
- Reading: Why is this so hard?
第 2 週
Introduction to the Dataset - Andrew Jaffe
This week, we'll really dig into the dataset by providing an introduction from Andrew Jaffe, the lead scientist on the analysis. You should also be looking ahead to Task 2, which is due in Week 4; the alignment will take a long time to perform, so you should start early.
1 個視頻, 3 個閱讀材料
- Reading: Phenotype information
- Reading: Getting the data from SRA
- Reading: Which samples to use
第 3 週
Understand the Problem
The purpose of genomic data science is to answer fundamental questions in biology. Before starting on the data analysis process, the first step is always to understand the scientific question you are trying to answer. Don't forget to stay on top of the alignment task due in Week 4; it will take a long time to accomplish and shouldn't be put off.
1 個視頻, 1 個閱讀材料
- Reading: Task 1 Instructions
- Discussion Prompt: What did you find challenging about task 1?
已評分: Understand the problem
第 4 週
Alignment
Once you have understood the problem, the next step is to obtain the raw data so that you can perform your analysis.
2 個項目
- Discussion Prompt: What did you find challenging about task 2?
已評分: Alignment
第 5 週
QC the Alignment
Now you have aligned the data, the next step is to do some quality control to make sure that the data are in good shape.
2 個項目
- Discussion Prompt: What did you find challenging about task 3?
已評分: QC the Alignment
第 6 週
Get Feature Counts
Now that you have performed alignment and quality control, the next step is to calculate the abundance of every gene in every sample.
2 個項目
- Discussion Prompt: What did you find challenging about task 4?
已評分: Get Feature Counts
第 7 週
Exploratory Analysis
After summarizing your genomic data the next step is to load the data into R for analysis with Bioconductor.
2 個項目
- Discussion Prompt: What did you find challenging about task 5?
已評分: Exploratory Analysis
第 8 週
Statistical Analysis
The next step is to perform a statistical analysis to detect genes that are differentially expressed.
2 個項目
- Discussion Prompt: What did you find challenging about task 6?
已評分: Statistical Analysis
第 9 週
Gene Set Analysis
In task 6, we have identified genes differentially expressed between fetal and adult brain. Now we will examine these results in a wider context.
3 個項目
- Discussion Prompt: What did you find challenging about task 7?
- Peer Review: Optional Peer Review of Your Report Draft
已評分: Gene Set Analysis
第 10 週
Describe Your Analysis
The next step is to document your work. One of the major issues in genomic data science is that there are so many steps in the process. If these steps are not documented well the result can be major problems.
2 個項目
- Discussion Prompt: What did you find challenging about task 8?
已評分: Describe Your Analysis
常見問題解答
運作方式
Coursework
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製作方
Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
價格
| 購買課程 | |
|---|---|
| 訪問課程材料 | 可用 |
| 訪問評分的材料 | 可用 |
| 收到最終成績 | 可用 |
| 獲得可共享的課程證書 | 可用 |
評分和審閱
good way of wrapping up everything we learned in the specialization :)
Quite time demanding when genomics is not your primary field, but I have learnt so much!
Really practical project in the genomics field!
Good application of the learnt techniques.