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返回到 基因组测序(生物信息学 II)

學生對 加州大学圣地亚哥分校 提供的 基因组测序(生物信息学 II) 的評價和反饋

4.7
216 個評分
44 個審閱

課程概述

You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics. In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together. In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab. Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance....

熱門審閱

SV

Jan 10, 2017

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

MP

Dec 08, 2017

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

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1 - 基因组测序(生物信息学 II) 的 25 個評論(共 42 個)

創建者 Olaf W

Oct 03, 2018

Great , interactive content. Well structured and explained.

創建者 Lucas M

Oct 09, 2018

Excellent course. I didn't have the time to follow the honor's track, but I've done it for other instances of the specialization and I can say that the interaction with Stepic works perfectly. Way to go, thank you!

創建者 Ce D

Dec 02, 2016

Very useful to my working project. My gratitude for all the staff of this course.

創建者 Federico R

Apr 17, 2017

It's really a great course. A must for everyone working with bioinformatic tools in order to understand some basics and limitations that ultimately leads to biological conclussions

創建者 俞文冰

Jan 23, 2017

Very good courses.

創建者 Ayaan H

Jun 27, 2016

Enjoyed this course!

創建者 Qianhao L

Aug 28, 2017

It would be great if all the slides for every week could be shared. The Bioinformatics II is much harder than the last level. They've made it easy to learn.

創建者 Naveen P

Jul 01, 2017

The course is well defined.

創建者 Ahmad M Y A

Dec 16, 2016

excellent

創建者 chenhyde628

Sep 25, 2016

wery

創建者 Enamul H

Apr 22, 2017

Excellent! I have learned a lot. Pavel Pevzner is a boss of bioinformatics.

創建者 Ricardo

Feb 22, 2018

Excellent course to get a sense of Genome sequencing , programming assignments really make you learn.

創建者 vibha h

May 18, 2017

Very nice course!

創建者 Yirou L

Dec 27, 2016

Very helpful to those biologist who wants to start a career in bioinformatics

創建者 Evgeny L

Jan 01, 2018

If you liked first course, you must take second course too, one of the most enjoyable and challenging courses available. It's great not only for bioinformaticians, but for people who are interested in algorithms and their application.

創建者 Nivedita S

Jul 24, 2017

I particularly enjoyed this course a lot more than the first! i felt it was more application oriented and intuitive.

創建者 Ricardo S

Oct 10, 2016

I learned a lot on this course. Sequencing, sequencing antibiotics. Ilumina sequencing using BaseSpace. I attended an Ilumina seminar in person ( that I found on the website and by serendipity was coming to my city) and understood everything, because the experience with this course. I wish you can connect the sections with relevant papers (Pavel have so many that is hard to choose one).

創建者 Hercules P N

Jun 09, 2017

These courses are consistently excellent. The are possiblly the best entry point for someone wishing to have a go at bioinformatics.

創建者 Swaroop V

Jan 10, 2017

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

創建者 Weidong X

Jul 30, 2016

good course!

創建者 Paolo B

May 09, 2017

Excellent and fun introduction to sequencing techniques. I found it harder than Bioinformatics I, but worth the effort.

創建者 Tomasz K

May 11, 2017

Great!

創建者 Mihai P

Dec 08, 2017

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

創建者 Philipp M

Oct 18, 2017

A really rewarding course! Definitely shifted up a gear compared to the preceding course, so I recommend doing this in the prescribed order.

創建者 Dr S C

Jul 05, 2018

Another excellent course. Great to be able to start from a basic idea and keep expanding it until we look back and see we've learnt how to solve quite a complex problem!