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返回到 基因组测序(生物信息学 II)

學生對 加州大学圣地亚哥分校 提供的 基因组测序(生物信息学 II) 的評價和反饋

4.6
287 個評分
61 條評論

課程概述

You may have heard a lot about genome sequencing and its potential to usher in an era of personalized medicine, but what does it mean to sequence a genome? Biologists still cannot read the nucleotides of an entire genome as you would read a book from beginning to end. However, they can read short pieces of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces. We will further learn about brute force algorithms and apply them to sequencing mini-proteins called antibiotics. In the first half of the course, we will see that biologists cannot read the 3 billion nucleotides of a human genome as you would read a book from beginning to end. However, they can read shorter fragments of DNA. In this course, we will see how graph theory can be used to assemble genomes from these short pieces in what amounts to the largest jigsaw puzzle ever put together. In the second half of the course, we will discuss antibiotics, a topic of great relevance as antimicrobial-resistant bacteria like MRSA are on the rise. You know antibiotics as drugs, but on the molecular level they are short mini-proteins that have been engineered by bacteria to kill their enemies. Determining the sequence of amino acids making up one of these antibiotics is an important research problem, and one that is similar to that of sequencing a genome by assembling tiny fragments of DNA. We will see how brute force algorithms that try every possible solution are able to identify naturally occurring antibiotics so that they can be synthesized in a lab. Finally, you will learn how to apply popular bioinformatics software tools to sequence the genome of a deadly Staphylococcus bacterium that has acquired antibiotics resistance....

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SV
2017年1月9日

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

MP
2017年12月7日

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

篩選依據:

1 - 基因组测序(生物信息学 II) 的 25 個評論(共 60 個)

創建者 Jan G

2020年2月2日

Course is abandoned, no support on forums, waiting for weeks for peer-reviews, images don't load in the interactive text and quizzes, links in assignments are broken. Coursera should refund me for this joke.

創建者 Hercules P N

2017年6月9日

These courses are consistently excellent. The are possiblly the best entry point for someone wishing to have a go at bioinformatics.

創建者 Ryan B

2019年5月6日

Long waits for peer review....ruins what is a good course.

創建者 Ксения

2017年9月6日

Spend a huge amount of time because of mistakes in tasks!

創建者 Jonathan L

2021年5月24日

The course is great, but be prepared to spend 20-30 hours a week on it...

創建者 Ricardo S

2016年10月10日

I learned a lot on this course. Sequencing, sequencing antibiotics. Ilumina sequencing using BaseSpace. I attended an Ilumina seminar in person ( that I found on the website and by serendipity was coming to my city) and understood everything, because the experience with this course. I wish you can connect the sections with relevant papers (Pavel have so many that is hard to choose one).

創建者 Daniel D

2019年10月8日

The course is absolutely fantastic. Concepts are introduced gradually, and you get away with solid fundamentals of genome sequences.

Beware however that the course is not actively maintained any longer and has few participants. It may be that your final assessment will take a bit to be graded by the peers and the forums are not super active.

創建者 Evgeny L

2018年1月1日

If you liked first course, you must take second course too, one of the most enjoyable and challenging courses available. It's great not only for bioinformaticians, but for people who are interested in algorithms and their application.

創建者 Lucas M

2018年10月9日

Excellent course. I didn't have the time to follow the honor's track, but I've done it for other instances of the specialization and I can say that the interaction with Stepic works perfectly. Way to go, thank you!

創建者 Swaroop V

2017年1月10日

Great course to explore a bit of Bioinformatics for those with no background in Bioinformatics. I love the way the content has been provided, its interactivity increases the interest in the course.

創建者 Mihai P

2017年12月8日

I like the real-world tasks, especially the assembly on the final exam. Some of the programming tasks, such as the antibiotic noisy spectrum assembly, are challenging (which is good).

創建者 Federico R

2017年4月17日

It's really a great course. A must for everyone working with bioinformatic tools in order to understand some basics and limitations that ultimately leads to biological conclussions

創建者 Samuel C

2018年7月5日

Another excellent course. Great to be able to start from a basic idea and keep expanding it until we look back and see we've learnt how to solve quite a complex problem!

創建者 Qianhao L

2017年8月27日

It would be great if all the slides for every week could be shared. The Bioinformatics II is much harder than the last level. They've made it easy to learn.

創建者 Philipp M

2017年10月18日

A really rewarding course! Definitely shifted up a gear compared to the preceding course, so I recommend doing this in the prescribed order.

創建者 CHAN V S F

2021年7月14日

The exercises were challenging. But thanks to the community in Stepik, I can understand more details for the genome sequencing algorithms.

創建者 Paolo B

2017年5月9日

Excellent and fun introduction to sequencing techniques. I found it harder than Bioinformatics I, but worth the effort.

創建者 David B

2017年7月25日

This is a well organized course with excellent interactive programming exercises that help with learning the concepts.

創建者 Nivedita S

2017年7月24日

I particularly enjoyed this course a lot more than the first! i felt it was more application oriented and intuitive.

創建者 Rudramani P

2019年8月24日

This one is great introductory course for physicist like who knows the computing but lacks biological background.

創建者 Ricardo

2018年2月22日

Excellent course to get a sense of Genome sequencing , programming assignments really make you learn.

創建者 Jeff L

2020年11月30日

great course for those with strong motivation and interest. but it is a difficulty one though

創建者 Ce D

2016年12月2日

Very useful to my working project. My gratitude for all the staff of this course.

創建者 Yirou L

2016年12月26日

Very helpful to those biologist who wants to start a career in bioinformatics

創建者 Zack X

2019年7月21日

In depth and comprehensive coverage of the topics in genetic data analysis.