課程信息
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立即開始,按照自己的計劃學習。
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可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為15 小時

建議:7 weeks of study, 2-4 hours per week...
可選語言

英語(English)

字幕:英語(English)...
100% online

100% online

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為15 小時

建議:7 weeks of study, 2-4 hours per week...
可選語言

英語(English)

字幕:英語(English)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 2 小時

Introduction & Shortcomings of Current Approaches

This module introduces you to the course, outlines the shortcomings of current toxicity testing approaches, and shows how EBT can help to overcome these shortcomings....
Reading
9 個視頻(共 66 分鐘), 3 個閱讀材料, 1 個測驗
Video9 個視頻
Welcome3分鐘
Introduction to the Course14分鐘
Introduction5分鐘
Shortcoming No. 1: Narrative Reviews7分鐘
Shortcoming No. 2: Bias in Reviews7分鐘
Shortcoming No. 3: Evidence Writing4分鐘
Shortcoming No. 4: External Validity10分鐘
Shortcoming No. 5: Assessing New Methods5分鐘
Shortcoming No. 6: Inadequate Reporting7分鐘
Reading3 個閱讀材料
Letter to Learners10分鐘
Course Learning Objectives10分鐘
Supporting reading10分鐘
Quiz1 個練習
Practice Quiz 18分鐘
2
完成時間(小時)
完成時間為 3 小時

History and Causation

This module explains how evidence-based toxicology originated and describes the driving forces for the initiative. In the second lesson, you will learn how to distinguish between correlation and causation as well as the main problems with drawing conclusions on the basis of correlations. The Bradford Hill criteria are introduced, along with examples for each criterion. You will also learn about mechanistic toxicology and mechanistic validation....
Reading
11 個視頻(共 138 分鐘), 2 個閱讀材料, 1 個測驗
Video11 個視頻
Personal First Exposures to Evidence-Based Medicine21分鐘
The Start of EBT16分鐘
The First Conference 2007 to the Start of the EBT Collaboration 201114分鐘
The Evidence-Based Toxicology Collaboration (EBTC)13分鐘
Introduction Causation vs. Correlation18分鐘
The Hill Principles of Epidemiology and their Relation to Toxicology16分鐘
The Problem of Causation in Toxicology16分鐘
Biomarker Concept in Mechanistic Toxicology4分鐘
Mechanistic Validation4分鐘
The Future of Causation in Complex Systems9分鐘
Reading2 個閱讀材料
Supporting reading10分鐘
Supporting reading10分鐘
Quiz1 個練習
Practice Quiz 210分鐘
3
完成時間(小時)
完成時間為 3 小時

Systematic Review and Meta-Analysis

This module shows how to perform systematic reviews and meta-analyses. You will learn the history of both methods and will receive step-by-step instructions on how to perform systematic reviews and meta-analyses using examples from the research activities of the instructors. ...
Reading
8 個視頻(共 101 分鐘), 2 個閱讀材料, 2 個測驗
Video8 個視頻
Systematic Reviews: Definition and Principles26分鐘
Systematic Reviews - Protocol Development15分鐘
Systematic Reviews - Protocol Development (Part 2)19分鐘
History5分鐘
Meta-analysis Guidelines7分鐘
Meta-analysis Protocol, Part 110分鐘
Meta-analysis Protocol, Part 212分鐘
Reading2 個閱讀材料
Supporting reading10分鐘
Supporting reading10分鐘
Quiz2 個練習
Practice Quiz 36分鐘
Mid-course exam30分鐘
4
完成時間(小時)
完成時間為 2 小時

Risk of Bias & Application to Test Methods Comparison

This module teaches you about possible biases that can be introduced at different stages of research. Each bias is explained with examples, including solutions for overcoming those biases. The second lesson covers systematic review of the zebrafish embryotoxicity test as a case study conducted by the Evidence-based Toxicology Collaboration (EBTC). You will go through all of the steps of the systematic review again to imprint the knowledge from module 3, but this systematic review will be related to a toxicological method....
Reading
8 個視頻(共 94 分鐘), 2 個閱讀材料, 1 個測驗
Video8 個視頻
Introduction to Risk of Bias Concept in Critical Appraisal of Studies26分鐘
Examples for Risk of Bias Tools 1: Cochrane Collboration4分鐘
Examples for Risk of Bias Tools 2: SYRCLE's RoB Tool5分鐘
Examples of Risk of Bias Tools 3: National Institute for Environmental Health Sciences (NIEHS) - OHAT12分鐘
Quality Assessment in Evidence-Based Toxicology7分鐘
Evidence-Based Toxicology (EBT) and Evidence-Based Toxicology Collaboration (EBTC)11分鐘
Zebrafish Systematic Review22分鐘
Reading2 個閱讀材料
Supporting reading10分鐘
Supporting reading10分鐘
Quiz1 個練習
Practice Quiz 410分鐘

講師

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Thomas Hartung

Professor
Environmental Health and Engineering
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Lena Smirnova

Research Associate
Center for Alternatives to Animal Testing

關於 Johns Hopkins University

The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world....

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