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返回到 发现 DNA 和蛋白质的突变(生物信息学 VI)

學生對 加州大学圣地亚哥分校 提供的 发现 DNA 和蛋白质的突变(生物信息学 VI) 的評價和反饋

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56 個評分

課程概述

In previous courses in the Specialization, we have discussed how to sequence and compare genomes. This course will cover advanced topics in finding mutations lurking within DNA and proteins. In the first half of the course, we would like to ask how an individual's genome differs from the "reference genome" of the species. Our goal is to take small fragments of DNA from the individual and "map" them to the reference genome. We will see that the combinatorial pattern matching algorithms solving this problem are elegant and extremely efficient, requiring a surprisingly small amount of runtime and memory. In the second half of the course, we will learn how to identify the function of a protein even if it has been bombarded by so many mutations compared to similar proteins with known functions that it has become barely recognizable. This is the case, for example, in HIV studies, since the virus often mutates so quickly that researchers can struggle to study it. The approach we will use is based on a powerful machine learning tool called a hidden Markov model. Finally, you will learn how to apply popular bioinformatics software tools applying hidden Markov models to compare a protein against a related family of proteins....

熱門審閱

TK

2016年6月28日

One of the best specialization on Coursera. Highly recommended for anyone who wants to apply his/her programming skills to fascinating real-world problems.

EJ

2021年7月31日

Great course! It opened my mind on the capabilities of algorithms beyond its intended purpose.

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1 - 发现 DNA 和蛋白质的突变(生物信息学 VI) 的 13 個評論(共 13 個)

創建者 Samuel C

2018年9月16日

創建者 Jason M

2020年6月23日

創建者 Mohamed A

2017年8月14日

創建者 Tamas K

2016年6月29日

創建者 Edgardo P F J

2021年7月31日

創建者 Ramiz G

2020年4月14日

創建者 Sakshar C

2020年7月1日

創建者 Zack X

2019年7月21日

創建者 Arsham M N

2022年4月1日

創建者 Mare B

2020年5月16日

創建者 Thomas L

2017年7月17日

創建者 Thomas G

2018年12月20日

創建者 Weidong X

2017年2月27日