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中級

完成時間大約為9 小時

建議:7 hours/week...

英語(English)

字幕:英語(English)

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中級

完成時間大約為9 小時

建議:7 hours/week...

英語(English)

字幕:英語(English)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 3 小時

Cracking the Genetic Code

In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)...
7 個視頻 (總計 45 分鐘), 4 個閱讀材料, 6 個測驗
7 個視頻
How to Speak DNA4分鐘
Cracking the Genetic Code4分鐘
The Building Blocks of DNA5分鐘
Packing it all in!6分鐘
Summing Up1分鐘
The Double Helix16分鐘
4 個閱讀材料
Timeline of DNA Discoveries10分鐘
Behind the Picture: Photo 51 (interview)10分鐘
(Not Really) The Last Word about DNA (video)10分鐘
Biochemistry: The Operating System of Life (video)10分鐘
6 個練習
How to Speak DNA6分鐘
Cracking the Genetic Code6分鐘
The Building Blocks of DNA8分鐘
Packing it all in!6分鐘
DNA Word Search2分鐘
Cracking the Genetic Code22分鐘
2
完成時間為 3 小時

Getting the Message Across: Transcription, Translation, and Replication

We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!...
8 個視頻 (總計 52 分鐘), 4 個閱讀材料, 9 個測驗
8 個視頻
Stop copying me! DNA Replication6分鐘
Central Dogma, Part I: Transcription8分鐘
Central Dogma, Part II: Translation7分鐘
Practical DNA: Polymerase Chain Reaction (PCR)8分鐘
Practical DNA: Gel Electrophoresis7分鐘
Summing Up3分鐘
DNA Replication3分鐘
4 個閱讀材料
The Case of the Silenced Scientist10分鐘
Labster: Crime Scene Investigation10分鐘
TED Talk: Drew Barry - Animations of Unseeable Biology (video)10分鐘
Protein Data Bank10分鐘
9 個練習
The Scene of the Crime4分鐘
Stop copying me! DNA Replication4分鐘
Central Dogma, Pt 1: Transcription8分鐘
Central Dogma, Pt 2: Translation6分鐘
Decipher the Secret Message2分鐘
Breaking the Code (aka Game of Codons)4分鐘
Polymerase Chain Reaction (PCR)4分鐘
Gel Electrophoresis6分鐘
Getting the Message Across16分鐘
3
完成時間為 3 小時

Manipulating DNA

In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media....
8 個視頻 (總計 46 分鐘), 5 個閱讀材料, 7 個測驗
8 個視頻
Slice and Dice: Restriction Enzymes10分鐘
Lights, Camera, Transformations6分鐘
Mutations, Mutations, Mutations!6分鐘
From Bananas to Papayas: Genetically Modified Organisms (GMOs)9分鐘
Summing Up4分鐘
Genetic Engineering1分鐘
Sickle Cell Anemia59
5 個閱讀材料
Labster: Molecular Cloning Simulation10分鐘
Creating Dolly (video)10分鐘
Genetic Engineering and Working with DNA (video)10分鐘
How did they make insulin from recombinant DNA? (article)10分鐘
Massive Review Reveals Consensus on GMO Safety (article)10分鐘
7 個練習
Freaky Fruit: Manipulating DNA6分鐘
Slice and Dice: Restriction Enzymes6分鐘
Lights, Camera, Transformations6分鐘
Mutations, mutations, mutations6分鐘
From Papayas to Bananas: Genetically Modified Organisms (GMOs)6分鐘
Help Felicia design a blue tomato!8分鐘
Manipulating DNA16分鐘
4
完成時間為 3 小時

DNA and Me

What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA....
9 個視頻 (總計 45 分鐘), 7 個閱讀材料, 6 個測驗
9 個視頻
Sanger Sequencing3分鐘
The Human Genome Project5分鐘
Mammoths, Mummies, and Microbes: Ancient DNA10分鐘
Me and My Family Tree8分鐘
DNA and My Health5分鐘
That's a wrap!5分鐘
Sanger Sequencing51
Human Genome Sequencing1分鐘
7 個閱讀材料
Labster: Next Generation Sequencing Simulation10分鐘
Cracking the Code of Life (video)10分鐘
Iceman Murder Mystery (video)10分鐘
Personal DNA Testing (video)10分鐘
My Career in Genomics: Antibiotic Resistance (video)10分鐘
My Career in Genomics: Cancer Biology (video)10分鐘
My Career in Genomics: Evolution (video)10分鐘
6 個練習
DNA: Our Genetic Blueprint2分鐘
Sanger Sequencing8分鐘
Me and My Family Tree4分鐘
DNA and My Health2分鐘
DNA and Me18分鐘
Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)4分鐘
4.7
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創建者 DRAug 26th 2018

The most fun I have ever had with a course! Both professors have an amazing talent for conveying information. I hope that they will teach another class!

創建者 FLJun 8th 2018

Highly recommended!\n\nAwesome method of presenting a classic, boring , course.

講師

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Caitlin Mullarkey

Assistant Professor
Health Sciences
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Felicia Vulcu

Assistant Professor
Biochemistry and Biomedical Sciences

關於 麦克马斯特大学

Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”. ...

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