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From Disease to Genes and Back, Novosibirsk State University

4.7
41 個評分
6 個審閱

課程信息

Human genetics explores the genetically determined similarities and differences between human beings. This scientific discipline encompasses a variety of related fields such as molecular genetics, genomics, population genetics and medical genetics. Study of human genetics can help to find answers to questions regarding the inheritance and development of different human phenotypes. The field of medical genetics is quickly growing and dynamically developing thanks to the new technologies such as the next-generation sequencing. Most human diseases have a genetic component. This genetic component varies by disease. Some rare diseases appear to be completely determined by the genome, whereas more common diseases arise from a complex interplay of many genes, the environment and chance. The understanding of how our genomes contribute to disease susceptibility offers the prospect of large gains: it may guide disease diagnostics and prognostics and help in developing new therapies. The overall goal of this course is to describe how the researchers find genes responsible for different diseases and how this information is used to better understand and fight these diseases. You will learn about current approaches for finding single genetic variants underlying monogenic (Mendelian) diseases and sets of variants responsible for more complex, multifactorial ones. Furthermore, you will learn how the identification of these genetic variants makes it possible to understand how the affected biological pathways lead to disease development. During the final week of the course, we will talk more about clinical applications of the genetic findings. Upon completing the course, you will be able to: - give examples of monogenic and complex disorders - recognise patterns of Mendelian inheritance of monogenic diseases; - understand and describe principles and methods of gene mapping ; - describe the main steps and principles of genome-wide association studies (GWAS); - give examples of modern technologies that are currently used to find variants underlying human diseases; - discuss the approaches to finding causative variants underlying complex disorders; - discuss the possibilities and areas of application of genetic findings....

熱門審閱

創建者 FL

Sep 27, 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

創建者 JQ

Dec 30, 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

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6 個審閱

創建者 Чуйко Эдуард Александрович

Nov 24, 2018

Очень классный курс. Прям видны огромные старания, которые стоят за этой работой! Годнотаааа. Просто огромное спасибо авторам курса за прекрасный материал! Даже после прохождения курса будет полезным возвращаться к нему. И отдельное спасибо за огромное количество дополнительного материала! В общем 10/10, мастхев.

創建者 farbod emami langroudi

Sep 27, 2018

Highly recommended!

An interesting, up-to-date course with eye-catching and well designed videos.

創建者 Artem Elmuratov

Sep 09, 2018

Good Course

創建者 Yujuan Gui

Apr 03, 2018

This course is well organised. The course materials are new. I've learnt many of the concepts in this course years ago. I feel many of my knowledge is outdated. This course is a great refreshment and add-on.

創建者 Rodrigo Valencia Ocampo

Mar 05, 2018

I love this course

創建者 JOHN QUINCY

Dec 30, 2017

Fun and interesting course. Great review of material I had forgotten, sadly.