課程信息
4.7
40 個評分
5 個審閱
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中級

中級

完成時間(小時)

完成時間大約為18 小時

建議:6 weeks of study, 3-5 hours a week...
可選語言

英語(English)

字幕:英語(English)...
100% online

100% online

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
中級

中級

完成時間(小時)

完成時間大約為18 小時

建議:6 weeks of study, 3-5 hours a week...
可選語言

英語(English)

字幕:英語(English)...

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 3 小時

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
Reading
7 個視頻(共 54 分鐘), 9 個閱讀材料, 9 個測驗
Video7 個視頻
Course Introduction1分鐘
Anatomy of the Human Genome13分鐘
Identifying Functionally Important Elements in the Human Reference Genome12分鐘
Genetic Polymorphism11分鐘
Interrogating Genetic Variation10分鐘
Week 1 Conclusion2分鐘
Reading9 個閱讀材料
Meet your Educators and Fellow Learners10分鐘
Course Navigation10分鐘
Typos in videos10分鐘
Recommended Pre-reading10分鐘
The Human Genome Project30分鐘
Recommended Pre-reading10分鐘
Recommended Pre-reading10分鐘
Recommended Pre-reading10分鐘
Glossary Week 110分鐘
Quiz9 個練習
Pre-lecture Questions6分鐘
Practice Quiz2分鐘
Pre-lecture Questions4分鐘
Practice Quiz2分鐘
Pre-lecture Questions4分鐘
Practice Quiz4分鐘
Pre-lecture Questions6分鐘
Practice Quiz2分鐘
Introduction. Human Genome8分鐘
2
完成時間(小時)
完成時間為 4 小時

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
Reading
7 個視頻(共 59 分鐘), 13 個閱讀材料, 13 個測驗
Video7 個視頻
Hardy-Weinberg Equilibrium8分鐘
Linkage Disequilibrium8分鐘
Natural Selection11分鐘
Genetic Drift9分鐘
Genetic Structure12分鐘
Week 2 Conclusion2分鐘
Reading13 個閱讀材料
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Glossary Week 210分鐘
Quiz13 個練習
Pre-lecture Questions4分鐘
Practice Quiz4分鐘
Pre-lecture Questions6分鐘
Practice Quiz4分鐘
Pre-lecture Questions4分鐘
Practice Quiz4分鐘
Pre-lecture Questions4分鐘
Practice Quiz2分鐘
Pre-lecture Questions4分鐘
Practice Quiz4分鐘
Pre-lecture Questions2分鐘
Practice Quiz4分鐘
Populational Genetics14分鐘
3
完成時間(小時)
完成時間為 3 小時

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
Reading
6 個視頻(共 51 分鐘), 10 個閱讀材料, 11 個測驗
Video6 個視頻
Linkage Analysis. Family Studies11分鐘
NGS for Studying Monogenic Disorders — Part I7分鐘
NGS for Studying Monogenic Disorders — Part II10分鐘
NGS for Studying Monogenic Disorders — Part III11分鐘
Week 3 Conclusion1分鐘
Reading10 個閱讀材料
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Mendelian disorders: discussion10分鐘
Glossary Week 310分鐘
Quiz11 個練習
Pre-lecture Questions2分鐘
Practice Quiz2分鐘
Pre-lecture Questions2分鐘
Practice Quiz2分鐘
Pre-lecture Questions2分鐘
Practice Quiz2分鐘
Pre-lecture Questions4分鐘
Practice Quiz2分鐘
Pre-lecture Questions2分鐘
Practice Quiz2分鐘
Mendelian Disorders10分鐘
4
完成時間(小時)
完成時間為 6 小時

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
Reading
10 個視頻(共 88 分鐘), 18 個閱讀材料, 19 個測驗
Video10 個視頻
Introduction to Genome-Wide Association Studies. Historical Overview12分鐘
GWAS Nowadays. Imputations10分鐘
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11分鐘
4.5. Population Stratification and its Consequences10分鐘
4.6. Analysis of Genetically Structured Populations9分鐘
4.7. Meta-analysis of GWAS Results: Theory and Background6分鐘
4.8. Quality Control of GWAS Array Data10分鐘
4.9. Meta-analysis of GWAS Results: Practical Details8分鐘
Week 4 Conclusion2分鐘
Reading18 個閱讀材料
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Recommended Pre-reading10分鐘
Additional Materials10分鐘
Additional Materials10分鐘
Glossary Week 410分鐘
Quiz19 個練習
Pre-lecture Questions4分鐘
Practice Quiz4分鐘
Pre-lecture Questions2分鐘
Practice Quiz6分鐘
Pre-lecture Questions2分鐘
Practice Quiz2分鐘
Pre-lecture Questions4分鐘
Post-lecture Questions4分鐘
Pre-lecture Questions2分鐘
Post-lecture Questions4分鐘
Pre-lecture Questions4分鐘
Post-lecture Questions6分鐘
Pre-lecture Questions2分鐘
Post-lecture Questions4分鐘
Pre-lecture Questions2分鐘
Post-lecture Questions2分鐘
Pre-lecture Questions2分鐘
Quiz4分鐘
Complex disorders26分鐘
4.7
5 個審閱Chevron Right
職業晉升

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創建者 FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

創建者 JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

講師

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Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

關於 Novosibirsk State University

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

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