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返回到 基因、蛋白质和基因组的对比(生物信息学 Ⅲ)

學生對 加州大学圣地亚哥分校 提供的 基因、蛋白质和基因组的对比(生物信息学 Ⅲ) 的評價和反饋

122 個評分
24 條評論


Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST....




A very well taught course that gives you the ins and outs of sequence comparision and introduces chromosme rearrangement analysis in a succint manner. This was



Take your time, this course is harder than the others. Very worth it though, learned a lot and it was a lot of fun!


1 - 基因、蛋白质和基因组的对比(生物信息学 Ⅲ) 的 24 個評論(共 24 個)

創建者 Ricardo S


One of the most difficult courses so far, but working hard you made it.

創建者 Yulan W


this course is easy understandable and interesting for the beginners!



Some content in Stepik might be erroneous...

創建者 Christiane A


for me this was a very intresting courde where I learined a lot about the research behind genetics especially how difficult it is to interprete the experiemntal data. I also like the mathematical background in graph theory.

Not being a boilogist I miss some extra inforamtion about the biological relevance and would like more pratical exemples before doing the final challenge which I found rather diffucult: only after reviewing my peers I really startd to onderstand the challenge.

What I also miss is the community building aspect. Therre is a forum on every page but the comment are usually very old (3 of more years) so you can't expect to have a dialogue anymore. Problems reported years ago are sill open. I also woud like to know how many learners are currently following this course.

創建者 Daniel D


It's simply astounding to see how clearly the authors managed to explain the concepts presented in the course (and in the entire series, for that matter). I always had a hunch that this was an excellent course, but only after reading other bioinformatics materials did it become clear to me how much effort the authors put into making this course the best that it can be.

My only criticism is that the peer reviewed final challenge doesn't work very well because there are not that many participants to do the peer reviews. It took me about 1 week to finish the course, including al programming challenges, and it's been 6 weeks since I am waiting to get my work graded. A better option would be to use an auto-grader.

創建者 Robert K


This was intensive, time-consuming, thought-provoking ... pleasure! I really enjoyed it, it took me more time than the schedule proposed, but it was worth it. I liked exploring things on my own, and tampering with the code/algorithms. This part of the course now assumes that you can think intelligently and will do so. Although this is a course in bioinformatics I often found myself laying on the bed with a piece of paper drawing graphs in order to fully grasp what I need to do so my code would be more efficient.

Excellent work! I'll start the next part now.

創建者 Roy M


I am a math and computer science person with no biology background. This course was on Chapters 5 and 6. I loved Chapter 5 because it was all about applications of the shortest path problem. I found the Challenge at the end of the course very hard, because of my weakness in biology. It seemed to really be about Chapter 4, and a very hard problem. But a really great sequence of courses!

創建者 Ayaan H


A very well taught course that gives you the ins and outs of sequence comparision and introduces chromosme rearrangement analysis in a succint manner. This was

創建者 Tobi F


Take your time, this course is harder than the others. Very worth it though, learned a lot and it was a lot of fun!

創建者 Hercules P N


I have taken courses I, II and III. They were consistently excellent. I plan to go for the next one.

創建者 Mario J C


Excellent course and the methodology used by the instructors is very appropriate. Thanks a lot.

創建者 Tuan N


Overall it is a nice course. I especially like the way pairwise alignment is explained.

創建者 Paolo B


This course was harder than the previous one, I am happy to have made it to the end!

創建者 Yasmine E H


Interesting course but I wish that it took less time to give me my certificate.

創建者 Zack X


In depth and comprehensive coverage of the topics in genetic data analysis.

創建者 Simon O


One of the most challenging courses that I have done.

創建者 Luis F R C


Very challenging but excellent walk through

創建者 Weidong X


a very good course!

創建者 Mohamed T


Excellent course

創建者 chenhyde628


Good coursera.

創建者 ­박준형 / 학 / 컴


Good class

創建者 José M P F


Muy bueno.

創建者 Yudi,Tian


I think I will need some pseudocode in stepik interactive material to complete the code challenge. some part still too confused to me

創建者 Linbo Z


I think Week 4 and 5 should be explained more. Pseudo-code can be more detailed.