課程信息
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27 reviews
A big welcome to “Bioinformatics: Introduction and Methods” from Peking University! In this MOOC you will become familiar with the concepts and computational methods in the exciting interdisciplinary field of bioinformatics and their applications in biology, the knowledge and skills in bioinformatics you acquired will help you in your future study and research. Course materials are available under the CC BY-NC-SA License....
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100% 在線課程

立即開始,按照自己的計劃學習。
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建議:1-2 hours/week

完成時間大約為18 小時
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English

字幕:English
Globe

100% 在線課程

立即開始,按照自己的計劃學習。
Calendar

可靈活調整截止日期

根據您的日程表重置截止日期。
Clock

建議:1-2 hours/week

完成時間大約為18 小時
Comment Dots

English

字幕:English

教學大綱 - 您將從這門課程中學到什麼

1

章節
Clock
完成時間為 2 小時

Introduction and History of Bioinformatics

Welcome to “Bioinformatics: Introduction and Methods! Upon completion of this module you will be able to: become familiar with the essential concepts of bioinformatics; explore the history of this young area; experience how rapidly bioinformatics is growing. Our supplementary materials will give you a better understanding of the course lectures through they are not required in quizzes or exams...
Reading
4 個視頻(共 69 分鐘), 2 個閱讀材料, 1 個測驗
Video4 個視頻
History of Bioinformatics30分鐘
Bioinformatics in Mainland China8分鐘
About This Course9分鐘
Reading2 個閱讀材料
Readings10分鐘
Slides10分鐘
Quiz1 個練習
Introduction and History of Bioinformatics20分鐘

2

章節
Clock
完成時間為 2 小時

Sequence Alignment

Upon completion of this module, you will be able to: describe dynamic programming based sequence alignment algorithms; differentiate between the Needleman-Wunsch algorithm for global alignment and the Smith-Waterman algorithm for local alignment; examine the principles behind gap penalty and time complexity calculation which is crucial for you to apply current bioinformatic tools in your research; experience the discovery of Smith-Waterman algorithm with Dr. Michael Waterman himself....
Reading
7 個視頻(共 99 分鐘), 2 個閱讀材料, 1 個測驗
Video7 個視頻
Global Alignment by Dynamic Programming14分鐘
From Global to Local6分鐘
Alignment with Affine Gap Penalty and Calculation of Time Complexity of The Needleman-Wunsch Algorithm6分鐘
Interview with M. S. Waterman Waterman29分鐘
Supplement on Homology & Similarity, Similarity Matrix and Dot Matrix (English Subtitles)10分鐘
Student Presentation (English Subtitles)18分鐘
Reading2 個閱讀材料
Readings10分鐘
Slides10分鐘
Quiz1 個練習
Sequence Alignment18分鐘

3

章節
Clock
完成時間為 1 小時

Sequence Database Search

Upon completion of this module, you will be able to: become familiar with sequence databse search and most common databases; explore the algoritm behind BLAST and the evaluation of BLAST results; ajdust BLAST parameters base on your own research project....
Reading
3 個視頻(共 41 分鐘), 2 個閱讀材料, 1 個測驗
Video3 個視頻
BLAST Algorithm: A Primer13分鐘
Student Presentation (English Subtitles)15分鐘
Reading2 個閱讀材料
Readings10分鐘
Slides10分鐘
Quiz1 個練習
Sequence Database Search10分鐘

4

章節
Clock
完成時間為 1 小時

Markov Model

Upon completion of this module, you will be able to: recognize state transitions, Markov chain and Markov models; create a hidden Markov model by yourself; make predictuions in a real biological problem with hidden Markov model....
Reading
4 個視頻(共 47 分鐘), 2 個閱讀材料, 1 個測驗
Video4 個視頻
Hidden Markov Model11分鐘
Predict with Hidden Markov Model10分鐘
Student Presentation16分鐘
Reading2 個閱讀材料
Readings10分鐘
Slides10分鐘
Quiz1 個練習
Markov Model 14分鐘

講師

Ge Gao 高歌, Ph.D.

Assistant Professor, Principle Investigator
Center for Bioinformatics, School of Life Science

Liping Wei 魏丽萍, Ph.D.

Professor, Director
Center for Bioinformatics, School of Life Sciences

關於 Peking University

Peking University is determined to make its education openly accessible to students in China and around the world. With over 3000 faculty members, Peking University offers excellence in teaching and learning. Founded in 1898, Peking University (PKU) was the first national comprehensive university in China. For the past 115 years, with its hundreds of thousands of outstanding alumni, Peking University has made prominent contributions in the humanities and sciences to further China's prosperity and progress....

常見問題

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

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