課程信息
4.7
184 個評分
37 個審閱
100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為11 小時

建議:12-18 hours of videos and labs...
可選語言

英語(English)

字幕:英語(English)
100% 在線

100% 在線

立即開始,按照自己的計劃學習。
可靈活調整截止日期

可靈活調整截止日期

根據您的日程表重置截止日期。
初級

初級

完成時間(小時)

完成時間大約為11 小時

建議:12-18 hours of videos and labs...
可選語言

英語(English)

字幕:英語(English)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間(小時)
完成時間為 3 小時

Protein Motifs

In this module we'll be exploring conserved regions within protein families. Such regions can help us understand the biology of a sequence, in that they are likely important for biological function, and also be used to help ascribe function to sequences where we can't identify any homologs in the databases. There are various ways of describing the conserved regions from simple regular expressions to profiles to profile hidden Markov models (HMMs)....
Reading
4 個視頻 (總計 34 分鐘), 4 個閱讀材料, 1 個測驗
Video4 個視頻
Lecture21分鐘
Lab Discussion9分鐘
Summary1分鐘
Reading4 個閱讀材料
Acknowledgements10分鐘
Course Logistics10分鐘
Lecture Materials10分鐘
Lab 1 -- Protein Domain, Motif and Profile Analysis30分鐘
Quiz1 個練習
Lab 1 Quiz6分鐘
2
完成時間(小時)
完成時間為 2 小時

Protein-Protein Interactions

In this module we'll be exploring protein-protein interactions (PPIs). Protein-protein interactions are important as proteins don't act in isolation, and often an examination of the interaction partners (determined in an unbiased, perhaps high throughput way) of a given protein can tell us a lot about its biology. We'll talk about some different methods used to determine PPIs and go over their strengths and weaknesses. In the lab we'll use 3 different tools and two different databases to examine interaction partners of BRCA2, a protein that we examined in last module's lab. Finally, we'll touch on a "foundational" concept, Gene Ontology (GO) term enrichment analysis, to help us understand in an overview way the proteins interacting with our example....
Reading
4 個視頻 (總計 37 分鐘), 2 個閱讀材料, 1 個測驗
Video4 個視頻
Lecture23分鐘
Lab Discussion11分鐘
Summary1分鐘
Reading2 個閱讀材料
Lecture Materials10分鐘
Lab 2 -- Protein-Protein Interactions30分鐘
Quiz1 個練習
Lab 2 Quiz6分鐘
3
完成時間(小時)
完成時間為 2 小時

Protein Structure

The determination of a protein's tertiary structure in three dimensions can tell us a lot about the biology of that protein. In this module's mini-lecture, we'll talk about some different methods used to determine a protein's tertiary structure and cover the main database for protein structure data, the PDB. In the lab we'll explore the PDB and an online tool for searching for structural (as opposed to sequence) similarity, VAST. We'll then use a nice piece of stand-alone software, PyMOL, to explore several protein structures in more detail....
Reading
4 個視頻 (總計 32 分鐘), 2 個閱讀材料, 1 個測驗
Video4 個視頻
Lecture13分鐘
Lab Discussion16分鐘
Summary1分鐘
Reading2 個閱讀材料
Lecture Materials10分鐘
Lab 3 -- Structural Bioinformatics30分鐘
Quiz1 個練習
Lab 3 Quiz6分鐘
4
完成時間(小時)
完成時間為 10 分鐘

Review: Protein Motifs, Protein-Protein Interactions, and Protein Structure

...
Reading
1 個測驗
Quiz1 個練習
Quiz: Protein Motifs, Protein-Protein Interactions, and Protein Structure10分鐘
4.7
37 個審閱Chevron Right
職業方向

20%

完成這些課程後已開始新的職業生涯
工作福利

25%

通過此課程獲得實實在在的工作福利
職業晉升

11%

加薪或升職

熱門審閱

創建者 RGApr 6th 2017

Gives the student real world exposure to the tools to study proteins gene regulation, etc. Instructor is involved and friendly. Highly recommended for someone who is interested in contemporary

創建者 NMJan 9th 2018

Hi Nicholas, Thank you so much for giving a lot of information. Bioinformatic Methods II was little difficult but understood after repeating the lad discussions. Thanks a lot.

講師

Avatar

Nicholas James Provart

Professor
Cell & Systems Biology

關於 University of Toronto

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

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