Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
提供方
課程信息
77,165 次近期查看
學生職業成果
24%
完成這些課程後已開始新的職業生涯
30%
通過此課程獲得實實在在的工作福利
17%
加薪或升職
可分享的證書
完成後獲得證書
100% 在線
立即開始，按照自己的計劃學習。
第 1 門課程（共 4 門）
可靈活調整截止日期
根據您的日程表重置截止日期。
初級
完成時間大約為20 小時
英語（English）
字幕：法語（French）, 巴西葡萄牙語, 俄語（Russian）, 英語（English）, 西班牙語（Spanish）
您將獲得的技能
Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics
學生職業成果
24%
完成這些課程後已開始新的職業生涯
30%
通過此課程獲得實實在在的工作福利
17%
加薪或升職
可分享的證書
完成後獲得證書
100% 在線
立即開始，按照自己的計劃學習。
第 1 門課程（共 4 門）
可靈活調整截止日期
根據您的日程表重置截止日期。
初級
完成時間大約為20 小時
英語（English）
字幕：法語（French）, 巴西葡萄牙語, 俄語（Russian）, 英語（English）, 西班牙語（Spanish）
提供方
多伦多大学
Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe.
教學大綱 - 您將從這門課程中學到什麼
完成時間為 3 小時
NCBI/Blast I
In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function.
完成時間為 3 小時
4 個視頻 （總計 51 分鐘）, 4 個閱讀材料, 1 個測驗
4 個閱讀材料
Acknowledgements10分鐘
Course Logistics10分鐘
Lecture Materials10分鐘
Lab 1 -- Exploring NCBI1 小時 30 分
1 個練習
Lab 1 Quiz30分鐘
完成時間為 3 小時
Blast II/Comparative Genomics
In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are.
完成時間為 3 小時
4 個視頻 （總計 58 分鐘）, 2 個閱讀材料, 1 個測驗
2 個閱讀材料
Lecture Materials10分鐘
Lab 2 -- Advanced Blast and Comparative Genomics1 小時 30 分
1 個練習
Lab 2 Quiz30分鐘
完成時間為 3 小時
Multiple Sequence Alignments
In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example.
完成時間為 3 小時
4 個視頻 （總計 44 分鐘）, 2 個閱讀材料, 1 個測驗
2 個閱讀材料
Lecture Materials10分鐘
Lab 3 -- Multiple Sequence Alignment1 小時 30 分
1 個練習
Lab 3 Quiz30分鐘
完成時間為 1 小時
Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments
完成時間為 1 小時
1 個練習
Quiz: Modules 1-330分鐘
審閱
來自生物信息学方法 I的熱門評論
由 SA 提供2020年7月11日
This course is very well organized, easy to understand, and explained everything steps by step which will help to grasp the concept easily. If you are a beginner like me, you should take this course.
由 ED 提供2017年4月26日
Great course. All lectures provide a biological context for the tools you learn in the labs. The labs themselves provide a great introduction to the many tools available for bioinformatic analysis.
由 RG 提供2017年11月4日
I enjoyed doing the course. It is exciting to see how much one can learn from a few gene or protein sequences. Thank you for making the course understandable to a beginner in bioinformatics!
由 FJ 提供2017年2月5日
The videos were very clear on how to use various bioinformatic tools. I found no difficulty in understanding them. Really enjoyed the course. Looking forward to the next part of this course!
關於 Plant Bioinformatic Methods 專項課程
The past 15 years have been exciting ones in plant biology. Hundreds of plant genomes have been sequenced, RNA-seq has enabled transcriptome-wide expression profiling, and a proliferation of "-seq"-based methods has permitted protein-protein and protein-DNA interactions to be determined cheaply and in a high-throughput manner. These data sets in turn allow us to generate hypotheses at the click of a mouse or tap of a finger.The Plant Bioinformatics Specialization on Coursera introduces core bioinformatic competencies and resources, such as NCBI's Genbank, Blast, multiple sequence alignments, phylogenetics in Bioinformatic Methods I, followed by protein-protein interaction, structural bioinformatics and RNA-seq analysis in Bioinformatic Methods II. In Plant Bioinformatics we cover 33 plant-specific online tools from genome browsers to transcriptomic data mining to promoter/network analyses and others. Last, a Plant Bioinformatics Capstone uses these tools to hypothesize a biological role for a gene of unknown function, summarized in a written lab report.This specialization is useful to any modern plant molecular biologist wanting to get a feeling for the incredible scope of data available to researchers. A small amount of R programming is introduced in Bioinformatic Methods II, but most of the tools are web applications. It is recommended that you have access to a laptop or desktop computer for running these as they may not work as mobile applications on your phone or tablet.
常見問題
我什么时候能够访问课程视频和作业？
讲座和作业的访问权限取决于您的注册类型。如果您以旁听模式参加课程，则可以免费查看大多数课程资料。要访问评分作业并获得证书，您需要在旁听期间或之后购买证书体验。如果看不到旁听选项：
- 课程可能不提供旁听选项。您可以尝试免费试用，也可以申请助学金。
- 课程可能会改为提供'完整课程，没有证书'。通过此选项，您可以查看所有课程材料、提交所要求的作业，以及获得最终成绩。这也意味着您将无法购买证书体验。
我订阅此专项课程后会得到什么？
您注册课程后，将有权访问专项课程中的所有课程，并且会在完成课程后获得证书。您的电子课程证书将添加到您的成就页中，您可以通过该页打印您的课程证书或将其添加到您的领英档案中。如果您只想阅读和查看课程内容，可以免费旁听课程。
Is financial aid available?
是的，Coursera 可以为无法承担费用的学生提供助学金。通过点击左侧“注册”按钮下的“助学金”链接可以申请助学金。您可以根据屏幕提示完成申请，申请获批后会收到通知。您需要针对专项课程中的每一门课程完成上述步骤，包括毕业项目。了解更多。
完成课程后，我会获得大学学分吗？
此课程不提供大学学分，但部分大学可能会选择接受课程证书作为学分。查看您的合作院校，了解详情。Coursera 上的在线学位和 Mastertrack™ 证书提供获得大学学分的机会。
還有其他問題嗎？請訪問 學生幫助中心。
