課程信息
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初級

完成時間大約為13 小時

建議:12-18 hours videos and labs...

英語(English)

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您將獲得的技能

Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics

100% 在線

立即開始,按照自己的計劃學習。

可靈活調整截止日期

根據您的日程表重置截止日期。

初級

完成時間大約為13 小時

建議:12-18 hours videos and labs...

英語(English)

字幕:英語(English)

教學大綱 - 您將從這門課程中學到什麼

1
完成時間為 3 小時

NCBI/Blast I

In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function.

...
4 個視頻 (總計 52 分鐘), 4 個閱讀材料, 1 個測驗
4 個視頻
Lecture25分鐘
Summary
4 個閱讀材料
Acknowledgements10分鐘
Course Logistics10分鐘
Lecture Materials10分鐘
Lab 1 -- Exploring NCBI1 小時 30 分
1 個練習
Lab 1 Quiz6分鐘
2
完成時間為 3 小時

Blast II/Comparative Genomics

In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are.

...
4 個視頻 (總計 58 分鐘), 2 個閱讀材料, 1 個測驗
4 個視頻
Lecture32分鐘
Summary
2 個閱讀材料
Lecture Materials10分鐘
Lab 2 -- Advanced Blast and Comparative Genomics1 小時 30 分
1 個練習
Lab 2 Quiz6分鐘
3
完成時間為 2 小時

Multiple Sequence Alignments

In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example.

...
4 個視頻 (總計 42 分鐘), 2 個閱讀材料, 1 個測驗
4 個視頻
Lecture23分鐘
Summary
2 個閱讀材料
Lecture Materials10分鐘
Lab 3 -- Multiple Sequence Alignment1 小時 30 分
1 個練習
Lab 3 Quiz6分鐘
4
完成時間為 10 分鐘

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

...
1 個測驗
1 個練習
Quiz: Modules 1-310分鐘
4.7
158 個審閱Chevron Right

21%

完成這些課程後已開始新的職業生涯

29%

通過此課程獲得實實在在的工作福利

20%

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來自生物信息学方法 I的熱門評論

創建者 EDApr 27th 2017

Great course. All lectures provide a biological context for the tools you learn in the labs. The labs themselves provide a great introduction to the many tools available for bioinformatic analysis.

創建者 FJFeb 6th 2017

The videos were very clear on how to use various bioinformatic tools. I found no difficulty in understanding them. Really enjoyed the course. Looking forward to the next part of this course!

講師

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Nicholas James Provart

Professor
Cell & Systems Biology

關於 多伦多大学

Established in 1827, the University of Toronto is one of the world’s leading universities, renowned for its excellence in teaching, research, innovation and entrepreneurship, as well as its impact on economic prosperity and social well-being around the globe. ...

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