Bioinformatic Methods I

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Bioinformatic Methods I

University of Toronto

Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on. Topics covered include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts. The first part, Bioinformatic Methods I (this one), deals with databases, Blast, multiple sequence alignments, phylogenetics, selection analysis and metagenomics. This, the second part, Bioinformatic Methods II, covers motif searching, protein-protein interactions, structural bioinformatics, gene expression data analysis, and cis-element predictions. This pair of courses is useful to any student considering graduate school in the biological sciences, as well as students considering molecular medicine. Both provide an overview of the many different bioinformatic tools that are out there. These courses are based on one taught at the University of Toronto to upper-level undergraduates who have some understanding of basic molecular biology. If you're not familiar with this, something like https://learn.saylor.org/course/bio101 might be helpful. No programming is required for this course....

100% 在線課程

立即開始，按照自己的計劃學習。

可靈活調整截止日期

根據您的日程表重置截止日期。

建議：12-18 hours videos and labs

完成時間大約為12 小時

English

字幕：English

您將獲得的技能

Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics

100% 在線課程

立即開始，按照自己的計劃學習。

可靈活調整截止日期

根據您的日程表重置截止日期。

建議：12-18 hours videos and labs

完成時間大約為12 小時

English

字幕：English

教學大綱 - 您將從這門課程中學到什麼

1

章節

完成時間為 3 小時

NCBI/Blast I

In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function. ...

4 個視頻（共 52 分鐘）, 4 個閱讀材料, 1 個測驗

4 個視頻

Introduction1分鐘

Lecture25分鐘

Lab Discussion24分鐘

Summary分鐘

4 個閱讀材料

Acknowledgements10分鐘

Course Logistics10分鐘

Lecture Materials10分鐘

Lab 1 -- Exploring NCBI30分鐘

1 個練習

Lab 1 Quiz6分鐘

2

章節

完成時間為 3 小時

Blast II/Comparative Genomics

In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are....

4 個視頻（共 58 分鐘）, 2 個閱讀材料, 1 個測驗

4 個視頻

Introduction2分鐘

Lecture32分鐘

Lab Discussion23分鐘

Summary分鐘

2 個閱讀材料

Lecture Materials10分鐘

Lab 2 -- Advanced Blast and Comparative Genomics30分鐘

1 個練習

Lab 2 Quiz6分鐘

3

章節

完成時間為 2 小時

Multiple Sequence Alignments

In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example....

4 個視頻（共 42 分鐘）, 2 個閱讀材料, 1 個測驗

4 個視頻

Introduction1分鐘

Lecture23分鐘

Lab Discussion16分鐘

Summary分鐘

2 個閱讀材料

Lecture Materials10分鐘

Lab 3 -- Multiple Sequence Alignment30分鐘

1 個練習

Lab 3 Quiz6分鐘

4

章節

完成時間為 10 分鐘

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

...

1 個測驗

1 個練習

Quiz: Modules 1-310分鐘

講師

Nicholas James Provart

Professor

Cell & Systems Biology

關於 University of Toronto

Established in 1827, the University of Toronto has one of the strongest research and teaching faculties in North America, presenting top students at all levels with an intellectual environment unmatched in depth and breadth on any other Canadian campus. ...

常見問題

When will I have access to the lectures and assignments?
Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.
What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
What is the refund policy?
Is financial aid available?

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Bioinformatic Methods I

Bioinformatic Methods I

100% 在線課程

可靈活調整截止日期

建議：12-18 hours videos and labs

English

您將獲得的技能

100% 在線課程

可靈活調整截止日期

建議：12-18 hours videos and labs

English

教學大綱 - 您將從這門課程中學到什麼

1

NCBI/Blast I

2

Blast II/Comparative Genomics

3

Multiple Sequence Alignments

4

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

18%

83%

25%

熱門審閱

講師

Nicholas James Provart

關於 University of Toronto

常見問題