課程信息
4.5
33 ratings
11 reviews
Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively....
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Intermediate Level

中級

Clock

建議:6 hours/week

完成時間大約為22 小時
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English

字幕:English
Globe

100% 在線課程

立即開始,按照自己的計劃學習。
Calendar

可靈活調整截止日期

根據您的日程表重置截止日期。
Intermediate Level

中級

Clock

建議:6 hours/week

完成時間大約為22 小時
Comment Dots

English

字幕:English

教學大綱 - 您將從這門課程中學到什麼

1

章節
Clock
完成時間為 3 小時

Electricity in Solutions

This week's theme focuses on the foundations of bioelectricity including electricity in solutions. The learning objectives for this week are: (1) Explain the conflict between Galvani and Volta; (2) Interpret the polarity of Vm in terms of voltages inside as compared to outside cells; (3) Interpret the polarity of Im in terms of current flow into or out of a cell.; (4) Determine the energy in Joules of an ordinary battery, given its specifications; (5) State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials....
Reading
12 個視頻(共 66 分鐘), 5 個閱讀材料, 2 個測驗
Video12 個視頻
What is the Question5分鐘
About Bioelectricity5分鐘
Major Sections of the Course5分鐘
Rectification of Names10分鐘
Ions in Solution6分鐘
Core-Conductor Model of a Nerve Fiber9分鐘
Potential and Voltages in the Fiber5分鐘
Axial Currents in the Fiber5分鐘
Membrane Resistance3分鐘
Membrane Current, Failure & Mystery3分鐘
Week 1 in Review4分鐘
Reading5 個閱讀材料
Welcome to the Course分鐘
Assessments, Grading and Certificates10分鐘
Course Lecture Slides10分鐘
Discussion Forums10分鐘
Reference Text10分鐘
Quiz2 個練習
Quiz 1A10分鐘
Quiz 1B16分鐘

2

章節
Clock
完成時間為 2 小時

Energy into Voltage

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest. The learning objectives for this week are: (1) Describe the function of the sodium-potassium pump; (2) State from memory an approximate value for RT/F; (3) Be able to find the equilibrium potential from ionic concentrations and relative permeabilities; (4) Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages....
Reading
12 個視頻(共 76 分鐘), 2 個測驗
Video12 個視頻
A Membrane Patch; the Idea of It7分鐘
Energy as Trans-membrane Voltage Vm3分鐘
Sodium-potassium Pumps4分鐘
Ionic equilibrium13分鐘
Battery lifetime5分鐘
Problem session 14分鐘
Membrane Resistance Rm9分鐘
Membrane capacitance Cm4分鐘
Why is Cm so big?7分鐘
Problem session, R and C8分鐘
Week 2 summary5分鐘
Quiz2 個練習
Quiz 2A20分鐘
Quiz 2B12分鐘

3

章節
Clock
完成時間為 2 小時

Passive and Active Resonses, Channels

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall. The learning objectives for this week are: (1) Describe the passive as compared to active responses to stimulation; (2) Describe the opening and closing of a channel in terms of probabilities; (3) Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities; (4) Compute how the channel probabilities change when voltage Vm changes....
Reading
12 個視頻(共 82 分鐘), 1 個閱讀材料, 3 個測驗
Video12 個視頻
Why are passive and active so different?3分鐘
The simulation set-up9分鐘
The passive simulation11分鐘
The active simulation11分鐘
Where does the active response come from?8分鐘
Problem session, passive v active6分鐘
Channels: Experimental isolation of a channel7分鐘
Channels: Observed currents, voltage step4分鐘
Channels: Probability of being open6分鐘
Problem session, Channel probabilities8分鐘
Week 3 Conclusions4分鐘
Reading1 個閱讀材料
Alpha Beta Programming Assignment Instructions10分鐘
Quiz3 個練習
Quiz 3A12分鐘
Quiz 3B18分鐘
Alpha Beta Programming Assignment24分鐘

4

章節
Clock
完成時間為 3 小時

Hodgkin-Huxley Membrane Models

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow. The learning objectives for this week are: (1) Describe the purpose of each of the 4 model levels 1. alpha/beta, 2. probabilities, 3. ionic currents and 4. trans-membrane voltage; (2) Estimate changes in each probability over a small interval $$\Delta t$$; (3) Compute the ionic current of potassium, sodium, and chloride from the state variables; (4) Estimate the change in trans-membrane potential over a short interval $$\Delta t$$; (5) State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery....
Reading
12 個視頻(共 95 分鐘), 1 個閱讀材料, 3 個測驗
Video12 個視頻
What is the Problem8分鐘
HH replacement for Rm5分鐘
The equation for each pathway10分鐘
Changes in n, m, h11分鐘
Equations for alphas and betas18分鐘
Problem session, I_Na9分鐘
Putting it all together6分鐘
Changes in n, m, h, and Vm5分鐘
Numerical calculations, time and space6分鐘
Problem session, a Vm step4分鐘
Week 4 conclusions5分鐘
Reading1 個閱讀材料
Action Potential Programming Assignment10分鐘
Quiz3 個練習
Quiz 4A16分鐘
Quiz 4B20分鐘
Action Potential Programming Assignment18分鐘
4.5

熱門審閱

創建者 JRSep 25th 2016

Very clear expectations, and the lectures were spaced out nicely to cover material while not being overwhelming. Additionally, the analogies used to convey the principles were clever and helpful!

創建者 AJJan 15th 2018

Interesting class which derived mathematical models that were, and are still used, to describe nerves.

講師

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

關於 Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

常見問題

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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